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Q5LUQ0

- CLPP_RUEPO

UniProt

Q5LUQ0 - CLPP_RUEPO

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Protein

ATP-dependent Clp protease proteolytic subunit

Gene
clpP, SPO1003
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071Nucleophile By similarity
Active sitei132 – 1321 By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit (EC:3.4.21.92)
Alternative name(s):
Endopeptidase Clp
Gene namesi
Name:clpP
Ordered Locus Names:SPO1003
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209ATP-dependent Clp protease proteolytic subunitUniRule annotationPRO_0000179648Add
BLAST

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.

Protein-protein interaction databases

STRINGi246200.SPO1003.

Structurei

3D structure databases

ProteinModelPortaliQ5LUQ0.
SMRiQ5LUQ0. Positions 12-203.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.

Phylogenomic databases

eggNOGiCOG0740.
HOGENOMiHOG000285833.
KOiK01358.
OMAiLLHSRIM.
OrthoDBiEOG6Z3KQ0.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LUQ0-1 [UniParc]FASTAAdd to Basket

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MFDPVDTYMN TLVPMVVEQT SRGERAYDIF SRLLKERIIF INGPIHDGMS    50
HLIVAQLLHL EAENPNKEIS IYINSPGGVV TSGLSIYDTM QYIKPKCSTL 100
VIGQAASMGS VLLAGGEKGM RFSLPNSRIM VHQPSGGYQG QASDIMIHAA 150
ETQKLKDRLY DIYVKHTGQT KKAVEKALDR DNFMSPEEAK EWGHIDEIVE 200
SRSKGDDAE 209
Length:209
Mass (Da):23,259
Last modified:February 1, 2005 - v1
Checksum:i9B4C8AA20DFBD150
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV94307.1.
RefSeqiYP_166255.2. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV94307; AAV94307; SPO1003.
GeneIDi3193881.
KEGGisil:SPO1003.
PATRICi23375299. VBIRuePom114501_1021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV94307.1 .
RefSeqi YP_166255.2. NC_003911.12.

3D structure databases

ProteinModelPortali Q5LUQ0.
SMRi Q5LUQ0. Positions 12-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246200.SPO1003.

Protein family/group databases

MEROPSi S14.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV94307 ; AAV94307 ; SPO1003 .
GeneIDi 3193881.
KEGGi sil:SPO1003.
PATRICi 23375299. VBIRuePom114501_1021.

Phylogenomic databases

eggNOGi COG0740.
HOGENOMi HOG000285833.
KOi K01358.
OMAi LLHSRIM.
OrthoDBi EOG6Z3KQ0.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiCLPP_RUEPO
AccessioniPrimary (citable) accession number: Q5LUQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi