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Q5LTR1

- GCH4_RUEPO

UniProt

Q5LTR1 - GCH4_RUEPO

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei225 – 2251May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:SPO1352
    OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
    Taxonomic identifieri246200 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
    ProteomesiUP000001023: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367GTP cyclohydrolase FolE2PRO_0000147723Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246200.SPO1352.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5LTR1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5LTR1-1 [UniParc]FASTAAdd to Basket

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    MNLHPRDIDE TPDRDAAAAA LAVLRRWASG ATSTEISELD PSVARLLPDA    50
    ALSNYPDLSR QYPEDFTVDA TYRAGLPDLQ NGPSSLIRGA KQQIQHVGIS 100
    NFRLPIRFHR KEGDDLTLET SVTGTVSLEA GKKGINMSRI MRSFYKHAER 150
    TFSFEVIEAA LDDYMTDLDS FDARIQMRFS YPERIESLRS GLSGYQYYDI 200
    ALELVEQGGE RLKIMHLDYV YSSTCPCSLE LSEHARSSRG QLATPHSQRS 250
    VARLSVVVDG DASCLWFEDL IALCRRAVPT ETQVMVKRED EQAFAELNAA 300
    NPIFVEDAAR LFCAELLADH RIGDFRVVAS HQESLHSHDA VSVLTEGATF 350
    ATASLDPRLF ATLFHVG 367
    Length:367
    Mass (Da):40,860
    Last modified:February 1, 2005 - v1
    Checksum:i02B274509D4DE7B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000031 Genomic DNA. Translation: AAV94640.1.
    RefSeqiYP_166594.1. NC_003911.12.

    Genome annotation databases

    EnsemblBacteriaiAAV94640; AAV94640; SPO1352.
    GeneIDi3193416.
    KEGGisil:SPO1352.
    PATRICi23376017. VBIRuePom114501_1374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000031 Genomic DNA. Translation: AAV94640.1 .
    RefSeqi YP_166594.1. NC_003911.12.

    3D structure databases

    ProteinModelPortali Q5LTR1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246200.SPO1352.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV94640 ; AAV94640 ; SPO1352 .
    GeneIDi 3193416.
    KEGGi sil:SPO1352.
    PATRICi 23376017. VBIRuePom114501_1374.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700808 / DSM 15171 / DSS-3.

    Entry informationi

    Entry nameiGCH4_RUEPO
    AccessioniPrimary (citable) accession number: Q5LTR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3