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Q5LTR1

- GCH4_RUEPO

UniProt

Q5LTR1 - GCH4_RUEPO

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, SPO1352
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei225 – 2251May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:SPO1352
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367GTP cyclohydrolase FolE2UniRule annotation
PRO_0000147723Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO1352.

Structurei

3D structure databases

ProteinModelPortaliQ5LTR1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LTR1-1 [UniParc]FASTAAdd to Basket

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MNLHPRDIDE TPDRDAAAAA LAVLRRWASG ATSTEISELD PSVARLLPDA    50
ALSNYPDLSR QYPEDFTVDA TYRAGLPDLQ NGPSSLIRGA KQQIQHVGIS 100
NFRLPIRFHR KEGDDLTLET SVTGTVSLEA GKKGINMSRI MRSFYKHAER 150
TFSFEVIEAA LDDYMTDLDS FDARIQMRFS YPERIESLRS GLSGYQYYDI 200
ALELVEQGGE RLKIMHLDYV YSSTCPCSLE LSEHARSSRG QLATPHSQRS 250
VARLSVVVDG DASCLWFEDL IALCRRAVPT ETQVMVKRED EQAFAELNAA 300
NPIFVEDAAR LFCAELLADH RIGDFRVVAS HQESLHSHDA VSVLTEGATF 350
ATASLDPRLF ATLFHVG 367
Length:367
Mass (Da):40,860
Last modified:February 1, 2005 - v1
Checksum:i02B274509D4DE7B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV94640.1.
RefSeqiYP_166594.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV94640; AAV94640; SPO1352.
GeneIDi3193416.
KEGGisil:SPO1352.
PATRICi23376017. VBIRuePom114501_1374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV94640.1 .
RefSeqi YP_166594.1. NC_003911.12.

3D structure databases

ProteinModelPortali Q5LTR1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 246200.SPO1352.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV94640 ; AAV94640 ; SPO1352 .
GeneIDi 3193416.
KEGGi sil:SPO1352.
PATRICi 23376017. VBIRuePom114501_1374.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiGCH4_RUEPO
AccessioniPrimary (citable) accession number: Q5LTR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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