Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5LTR1 (GCH4_RUEPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:SPO1352
OrganismRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) [Complete proteome] [HAMAP]
Taxonomic identifier246200 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147723

Sites

Site2251May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5LTR1 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 02B274509D4DE7B1

FASTA36740,860
        10         20         30         40         50         60 
MNLHPRDIDE TPDRDAAAAA LAVLRRWASG ATSTEISELD PSVARLLPDA ALSNYPDLSR 

        70         80         90        100        110        120 
QYPEDFTVDA TYRAGLPDLQ NGPSSLIRGA KQQIQHVGIS NFRLPIRFHR KEGDDLTLET 

       130        140        150        160        170        180 
SVTGTVSLEA GKKGINMSRI MRSFYKHAER TFSFEVIEAA LDDYMTDLDS FDARIQMRFS 

       190        200        210        220        230        240 
YPERIESLRS GLSGYQYYDI ALELVEQGGE RLKIMHLDYV YSSTCPCSLE LSEHARSSRG 

       250        260        270        280        290        300 
QLATPHSQRS VARLSVVVDG DASCLWFEDL IALCRRAVPT ETQVMVKRED EQAFAELNAA 

       310        320        330        340        350        360 
NPIFVEDAAR LFCAELLADH RIGDFRVVAS HQESLHSHDA VSVLTEGATF ATASLDPRLF 


ATLFHVG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000031 Genomic DNA. Translation: AAV94640.1.
RefSeqYP_166594.1. NC_003911.12.

3D structure databases

ProteinModelPortalQ5LTR1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246200.SPO1352.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV94640; AAV94640; SPO1352.
GeneID3193416.
KEGGsil:SPO1352.
PATRIC23376017. VBIRuePom114501_1374.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMAYSSACPC.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_RUEPO
AccessionPrimary (citable) accession number: Q5LTR1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: February 1, 2005
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways