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Q5LTP7 (ILVC_RUEPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase

EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:SPO1366
OrganismRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) [Complete proteome] [HAMAP]
Taxonomic identifier246200 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Ketol-acid reductoisomerase HAMAP-Rule MF_00435
PRO_0000226202

Sites

Active site1081 Potential

Sequences

Sequence LengthMass (Da)Tools
Q5LTP7 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 7701AF7E7F7A3F0C

FASTA34037,019
        10         20         30         40         50         60 
MRVYYDRDCD INLIKDKKVA ILGYGSQGHA HALNLRDSGA KNLVVALREG SASAKKAEGE 

        70         80         90        100        110        120 
GLTVMGIAEA AAWCDVIMFT MPDELQAETY KKYVHDNIRP GAAIAFAHGL NVHFGLIEPK 

       130        140        150        160        170        180 
EGVDVIMMAP KGPGHTVRGE YTKGGGVPCL VAVHTDATGK ALEIGLSYCS AIGGGRSGII 

       190        200        210        220        230        240 
ETNFREECET DLFGEQAVLC GGLVELIRCG FETLVEAGYA PEMAYFECLH EVKLIVDLIY 

       250        260        270        280        290        300 
EGGIANMDYS ISNTAEYGQY VTGPRILPYE QTKASMKAVL TDIQQGKFVR DFMLENAVGQ 

       310        320        330        340 
PTIKASRRAN DEHQIEQVGQ KLRDMMPWIS AGKMVDKSKN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000031 Genomic DNA. Translation: AAV94654.1.
RefSeqYP_166608.1. NC_003911.12.

3D structure databases

ProteinModelPortalQ5LTP7.
SMRQ5LTP7. Positions 1-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246200.SPO1366.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV94654; AAV94654; SPO1366.
GeneID3193655.
KEGGsil:SPO1366.
PATRIC23376051. VBIRuePom114501_1391.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHOG000016230.
KOK00053.
OMAQSDVIMA.
OrthoDBEOG625K07.

Enzyme and pathway databases

UniPathwayUPA00047; UER00056.
UPA00049; UER00060.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
HAMAPMF_00435. IlvC.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERPTHR21371. PTHR21371. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_RUEPO
AccessionPrimary (citable) accession number: Q5LTP7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways