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Q5LTP7

- ILVC_RUEPO

UniProt

Q5LTP7 - ILVC_RUEPO

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Protein
Ketol-acid reductoisomerase
Gene
ilvC, SPO1366
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation
(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081 Reviewed prediction

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketol-acid reductoisomerase (EC:1.1.1.86)
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene namesi
Name:ilvC
Ordered Locus Names:SPO1366
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Ketol-acid reductoisomeraseUniRule annotation
PRO_0000226202Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO1366.

Structurei

3D structure databases

ProteinModelPortaliQ5LTP7.
SMRiQ5LTP7. Positions 1-329.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0059.
HOGENOMiHOG000016230.
KOiK00053.
OMAiQSDVIMA.
OrthoDBiEOG625K07.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00465. ilvC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5LTP7-1 [UniParc]FASTAAdd to Basket

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MRVYYDRDCD INLIKDKKVA ILGYGSQGHA HALNLRDSGA KNLVVALREG    50
SASAKKAEGE GLTVMGIAEA AAWCDVIMFT MPDELQAETY KKYVHDNIRP 100
GAAIAFAHGL NVHFGLIEPK EGVDVIMMAP KGPGHTVRGE YTKGGGVPCL 150
VAVHTDATGK ALEIGLSYCS AIGGGRSGII ETNFREECET DLFGEQAVLC 200
GGLVELIRCG FETLVEAGYA PEMAYFECLH EVKLIVDLIY EGGIANMDYS 250
ISNTAEYGQY VTGPRILPYE QTKASMKAVL TDIQQGKFVR DFMLENAVGQ 300
PTIKASRRAN DEHQIEQVGQ KLRDMMPWIS AGKMVDKSKN 340
Length:340
Mass (Da):37,019
Last modified:February 1, 2005 - v1
Checksum:i7701AF7E7F7A3F0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV94654.1.
RefSeqiYP_166608.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV94654; AAV94654; SPO1366.
GeneIDi3193655.
KEGGisil:SPO1366.
PATRICi23376051. VBIRuePom114501_1391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV94654.1 .
RefSeqi YP_166608.1. NC_003911.12.

3D structure databases

ProteinModelPortali Q5LTP7.
SMRi Q5LTP7. Positions 1-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246200.SPO1366.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV94654 ; AAV94654 ; SPO1366 .
GeneIDi 3193655.
KEGGi sil:SPO1366.
PATRICi 23376051. VBIRuePom114501_1391.

Phylogenomic databases

eggNOGi COG0059.
HOGENOMi HOG000016230.
KOi K00053.
OMAi QSDVIMA.
OrthoDBi EOG625K07.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00056 .
UPA00049 ; UER00060 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
HAMAPi MF_00435. IlvC.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view ]
PANTHERi PTHR21371. PTHR21371. 1 hit.
Pfami PF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00465. ilvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiILVC_RUEPO
AccessioniPrimary (citable) accession number: Q5LTP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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