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Protein

Pyrroloquinoline-quinone synthase

Gene

pqqC

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.UniRule annotation

Catalytic activityi

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O.UniRule annotation

Pathwayi: pyrroloquinoline quinone biosynthesis

This protein is involved in the pathway pyrroloquinoline quinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pyrroloquinoline quinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

PQQ biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00539.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroloquinoline-quinone synthaseUniRule annotation (EC:1.3.3.11UniRule annotation)
Alternative name(s):
Coenzyme PQQ synthesis protein CUniRule annotation
Pyrroloquinoline quinone biosynthesis protein CUniRule annotation
Gene namesi
Name:pqqCUniRule annotation
Ordered Locus Names:SPO1502
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000001023 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002199881 – 241Pyrroloquinoline-quinone synthaseAdd BLAST241

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO1502.

Structurei

3D structure databases

ProteinModelPortaliQ5LTB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PqqC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41086XE. Bacteria.
COG5424. LUCA.
HOGENOMiHOG000217947.
KOiK06137.
OMAiCNALIFK.
OrthoDBiPOG091H0KR9.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5LTB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSREDLEARL RAIGAERYHD KHPFHHKLHG GDCTPDQVRA WVINRWAYQA
60 70 80 90 100
AIPMKDAAFL SRCADPDIRR AWRSRIEDHD GGVDSGGGLR RWLKLAEAVG
110 120 130 140 150
LDPDYVASGR GILPATRFAV EAYFHYVREQ PLLQAVASSL TELFAPKIHE
160 170 180 190 200
NRIEGLLRHY DFADESSLSY FRKRLSEAPR DVAYGLGWVL DHADTPEKED
210 220 230 240
MACAALIFKT DVLWAQLDAL WGAYVDGHVP PGAWRPGEGM A
Length:241
Mass (Da):27,175
Last modified:February 1, 2005 - v1
Checksum:i797860F3D7E1B90B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV94789.1.
RefSeqiWP_011047239.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV94789; AAV94789; SPO1502.
KEGGisil:SPO1502.
PATRICi23376321. VBIRuePom114501_1525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV94789.1.
RefSeqiWP_011047239.1. NC_003911.12.

3D structure databases

ProteinModelPortaliQ5LTB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246200.SPO1502.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV94789; AAV94789; SPO1502.
KEGGisil:SPO1502.
PATRICi23376321. VBIRuePom114501_1525.

Phylogenomic databases

eggNOGiENOG41086XE. Bacteria.
COG5424. LUCA.
HOGENOMiHOG000217947.
KOiK06137.
OMAiCNALIFK.
OrthoDBiPOG091H0KR9.

Enzyme and pathway databases

UniPathwayiUPA00539.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPQQC_RUEPO
AccessioniPrimary (citable) accession number: Q5LTB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.