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Reviewed, UniProtKB/Swiss-Prot Q5LT54 (FOLD2_SILPO)

Last modified November 25, 2008. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Bifunctional protein folD 2
Including the following 2 domains:
    1- Recommended name:
            Methylenetetrahydrofolate dehydrogenase
              EC=1.5.1.5
    2- Recommended name:
            Methenyltetrahydrofolate cyclohydrolase
              EC=3.5.4.9
Gene names
Name: folD2
Ordered Locus Names: SPO1560
OrganismSilicibacter pomeroyi [Complete proteome] [HAMAP]
Taxonomic identifier89184 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeSilicibacter

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity.

Catalytic activity

5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.

5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.

Pathway

One-carbon metabolism; tetrahydrofolate pathway.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Bifunctional protein folD 2
PRO_0000268502

Sequences

Sequence LengthMass (Da)Tools
Q5LT54-1 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 9517A3C932983280

FASTA29230,883
        10         20         30         40         50         60 
MSTVADTRLL PGKPVRARIL SEVSAYVNQV GRIGKLVSIS IGNVPEVAVY VRNQARAASA 

        70         80         90        100        110        120 
VGVPFDQQLW DRSISQEVCQ SLIREMNDDP DVLGIILQRP VPDHINVRAL QAAIHPLKDV 

       130        140        150        160        170        180 
EGMNPASIGN IVYNDVAMAP CTAAAAIELI RETGLSMAGL EVVMVGHSEI VGKPVAMMLM 

       190        200        210        220        230        240 
AEGATVTVCH HMTRSDAMHS RRADVVVVAV GKAHLIGPDM IKPGAVVIDI GINHVPGPDG 

       250        260        270        280        290 
PVVVGDVQTD AVKDVAGWIT PVPGGVGLVT VAILLRNAIR AHQQQRAAGW IH 

« Hide

Cross-references

Sequence databases

CP000031 Genomic DNA. Translation: AAV94847.1.
RefSeqYP_166801.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3193492.
GenomeReviewsGene locus SPO1560 in contig CP000031_GR.
KEGGsil:SPO1560.
NMPDRfig|246200.3.peg.1970.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ5LT54.

Enzyme and pathway databases

BioCycSPOM246200:SPO_1560-MON.

Family and domain databases

HAMAPMF_01576.
[Tree]
InterProIPR016040. NAD(P)-bd.
IPR000672. THF_DHase/CycOHase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
ProDomPD002300. THFDhg/Cyc_hydro. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00766. THF_DHG_CYH_1. False negative.
PS00767. THF_DHG_CYH_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLD2_SILPO
AccessionPrimary (citable) accession number: Q5LT54
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 1, 2005
Last modified: November 25, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents