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Q5LSU1

- LPXB_RUEPO

UniProt

Q5LSU1 - LPXB_RUEPO

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:SPO1675
    OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
    Taxonomic identifieri246200 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
    ProteomesiUP000001023: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Lipid-A-disaccharide synthasePRO_0000255226Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246200.SPO1675.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5LSU1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiIAGQSHT.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5LSU1-1 [UniParc]FASTAAdd to Basket

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    MRPAGPVPVC CRAGRLMRVF ILAGEPSGDR LGGALMAGLR QLCPDVQFDG    50
    VGGPAMESEG LSSRFPMAEL SIMGLVEVLP KYFHLKRRIA ETAQAVLAMR 100
    PDVMITIDSP DFSLRVARLV KDASDIRTVH YVAPSVWAWR PGRADKMAKV 150
    IDHVLALLPF EPPYMERAGM ECDFVGHPVV TEPEATGADI AALRTELGLG 200
    AAPVLLALPG SRRGEVERLA PVFGAALRRF LPEHPDMRVV VPVVPHVADQ 250
    VAQQVAEWPG APVLVDPRGL APAQAAMRKR AAFAAADLAL AASGTVSLEL 300
    AAAGTPMVIA YKVNWLTQKI AERMVTIDTV TLVNLVSETR VVPECLGPAC 350
    TPENIAARLA AVHADPAAQD AAMRLTMERL GRGGTPPGLR AAQAVLDRLP 400
    G 401
    Length:401
    Mass (Da):42,664
    Last modified:February 1, 2005 - v1
    Checksum:iAAE8DB2FA164182D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000031 Genomic DNA. Translation: AAV94960.1.
    RefSeqiYP_166914.1. NC_003911.12.

    Genome annotation databases

    EnsemblBacteriaiAAV94960; AAV94960; SPO1675.
    GeneIDi3194064.
    KEGGisil:SPO1675.
    PATRICi23376675. VBIRuePom114501_1702.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000031 Genomic DNA. Translation: AAV94960.1 .
    RefSeqi YP_166914.1. NC_003911.12.

    3D structure databases

    ProteinModelPortali Q5LSU1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246200.SPO1675.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV94960 ; AAV94960 ; SPO1675 .
    GeneIDi 3194064.
    KEGGi sil:SPO1675.
    PATRICi 23376675. VBIRuePom114501_1702.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi IAGQSHT.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700808 / DSM 15171 / DSS-3.

    Entry informationi

    Entry nameiLPXB_RUEPO
    AccessioniPrimary (citable) accession number: Q5LSU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3