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Q5LQJ5 (FABH_SILPO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.41
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III
Gene names
Name:fabH
Ordered Locus Names:SPO2494
OrganismSilicibacter pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) [Complete proteome] [HAMAP]
Taxonomic identifier246200 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Ruegeria

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm Probable HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Lipid synthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Multifunctional enzyme
Gene Ontology (GO)
   Biological processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-oxoacyl-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3233233-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
PRO_1000056410

Regions

Region251 – 2555ACP-binding By similarity

Sites

Active site1141 By similarity
Active site2501 By similarity
Active site2801 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5LQJ5 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 571B185BAA34AF1E

FASTA32334,131
        10         20         30         40         50         60 
MAGRAVVKGV GHYLPERVVP NAAFEKTLDT TDEWIRSRSG IERRHFAAEG ETTSDLATRA 

        70         80         90        100        110        120 
AEAALADAGI SAEQIDAIVL ATSTADLTFP SAATMVQARL GMTNGYAFDV QAVCAGFVYA 

       130        140        150        160        170        180 
LSNANALIVS GQAKRVLVIG AETFSRIMDW TDRSTCVLFG DGAGALVLEY EEGEGTPQDR 

       190        200        210        220        230        240 
GILSVDLNSD GRYKDLLYVD GGVSTQTTGH LRMQGNQVFR HAVEKLAQTA ETALDKAGLS 

       250        260        270        280        290        300 
SADVDWIVPH QANIRIIQGT AKKMGLPMDK VVVTVQDHGN TSAASIPLAL SVGKARGQIK 

       310        320 
TGDLVVTEAI GGGLAWGAVV LRW

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000031 Genomic DNA. Translation: AAV95745.1.
RefSeqYP_167710.1. NC_003911.11.

3D structure databases

HSSPHSSP built from PDB template 1HNK based on UniProtKB P0A6R0.
ProteinModelPortalQ5LQJ5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3194497.
GenomeReviewsGene locus SPO2494 in contig CP000031_GR.
KEGGsil:SPO2494.
NMPDRfig|246200.3.peg.2884.
PATRIC23378385. VBIRuePom114501_2543.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMADAYIRGG.
ProtClustDBCLSK933877.

Enzyme and pathway databases

BioCycRPOM246200:SPO_2494-MONOMER.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABH_SILPO
AccessionPrimary (citable) accession number: Q5LQJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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