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Q5LPG8

- ASPD_RUEPO

UniProt

Q5LPG8 - ASPD_RUEPO

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Protein
Probable L-aspartate dehydrogenase
Gene
nadX, SPO2880
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NAD; via amide nitrogen By similarity
Binding sitei196 – 1961NAD By similarity
Active sitei226 – 2261 By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP
  3. aspartate dehydrogenase activity Source: UniProtKB-EC
  4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. NADP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenase (EC:1.4.1.21)
Gene namesi
Name:nadX
Ordered Locus Names:SPO2880
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Probable L-aspartate dehydrogenaseUniRule annotation
PRO_0000144892Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO2880.

Structurei

3D structure databases

ProteinModelPortaliQ5LPG8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000206326.
KOiK06989.
OMAiECAGHSA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01265. NadX.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5LPG8-1 [UniParc]FASTAAdd to Basket

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MWKLWGSWPE GDRVRIALIG HGPIAAHVAA HLPVGVQLTG ALCRPGRDDA    50
ARAALGVSVA QALEGLPQRP DLLVDCAGHS GLRAHGLTAL GAGVEVLTVS 100
VGALADAVFC AELEDAARAG GTRLCLASGA IGALDALAAA AMGTGLQVTY 150
TGRKPPQGWR GSRAEKVLDL KALTGPVTHF TGTARAAAQA YPKNANVAAA 200
VALAGAGLDA TRAELIADPG AAANIHEIAA EGAFGRFRFQ IEGLPLPGNP 250
RSSALTALSL LAALRQRGAA IRPSF 275
Length:275
Mass (Da):27,808
Last modified:February 1, 2005 - v1
Checksum:iD98084319F319CD8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV96121.1.
RefSeqiYP_168088.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV96121; AAV96121; SPO2880.
GeneIDi3195767.
KEGGisil:SPO2880.
PATRICi23379185. VBIRuePom114501_2938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV96121.1 .
RefSeqi YP_168088.1. NC_003911.12.

3D structure databases

ProteinModelPortali Q5LPG8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246200.SPO2880.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV96121 ; AAV96121 ; SPO2880 .
GeneIDi 3195767.
KEGGi sil:SPO2880.
PATRICi 23379185. VBIRuePom114501_2938.

Phylogenomic databases

eggNOGi COG1712.
HOGENOMi HOG000206326.
KOi K06989.
OMAi ECAGHSA.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00456 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01265. NadX.
InterProi IPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiASPD_RUEPO
AccessioniPrimary (citable) accession number: Q5LPG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: February 1, 2005
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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