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Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable L-aspartate dehydrogenase (nadX)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130NAD; via amide nitrogenUniRule annotation1
Binding sitei196NADUniRule annotation1
Active sitei226UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:SPO2880
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000001023 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448921 – 275Probable L-aspartate dehydrogenaseAdd BLAST275

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO2880

Structurei

3D structure databases

ProteinModelPortaliQ5LPG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Q27 Bacteria
COG1712 LUCA
HOGENOMiHOG000206326
KOiK06989
OMAiMIMSVGA
OrthoDBiPOG091H0M4V

Family and domain databases

HAMAPiMF_01265 NadX, 1 hit
InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR002811 Asp_DH
IPR020626 Asp_DH_prok
IPR011182 L-Asp_DH
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01958 DUF108, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF005227 Asp_dh_NAD_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q5LPG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKLWGSWPE GDRVRIALIG HGPIAAHVAA HLPVGVQLTG ALCRPGRDDA
60 70 80 90 100
ARAALGVSVA QALEGLPQRP DLLVDCAGHS GLRAHGLTAL GAGVEVLTVS
110 120 130 140 150
VGALADAVFC AELEDAARAG GTRLCLASGA IGALDALAAA AMGTGLQVTY
160 170 180 190 200
TGRKPPQGWR GSRAEKVLDL KALTGPVTHF TGTARAAAQA YPKNANVAAA
210 220 230 240 250
VALAGAGLDA TRAELIADPG AAANIHEIAA EGAFGRFRFQ IEGLPLPGNP
260 270
RSSALTALSL LAALRQRGAA IRPSF
Length:275
Mass (Da):27,808
Last modified:February 1, 2005 - v1
Checksum:iD98084319F319CD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA Translation: AAV96121.1

Genome annotation databases

EnsemblBacteriaiAAV96121; AAV96121; SPO2880
KEGGisil:SPO2880

Similar proteinsi

Entry informationi

Entry nameiASPD_RUEPO
AccessioniPrimary (citable) accession number: Q5LPG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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