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Q5LPG8 (ASPD_RUEPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase

EC=1.4.1.21
Gene names
Name:nadX
Ordered Locus Names:SPO2880
OrganismRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) [Complete proteome] [HAMAP]
Taxonomic identifier246200 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP-Rule MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP-Rule MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP-Rule MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Probable L-aspartate dehydrogenase HAMAP-Rule MF_01265
PRO_0000144892

Sites

Active site2261 By similarity
Binding site1301NAD; via amide nitrogen By similarity
Binding site1961NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5LPG8 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: D98084319F319CD8

FASTA27527,808
        10         20         30         40         50         60 
MWKLWGSWPE GDRVRIALIG HGPIAAHVAA HLPVGVQLTG ALCRPGRDDA ARAALGVSVA 

        70         80         90        100        110        120 
QALEGLPQRP DLLVDCAGHS GLRAHGLTAL GAGVEVLTVS VGALADAVFC AELEDAARAG 

       130        140        150        160        170        180 
GTRLCLASGA IGALDALAAA AMGTGLQVTY TGRKPPQGWR GSRAEKVLDL KALTGPVTHF 

       190        200        210        220        230        240 
TGTARAAAQA YPKNANVAAA VALAGAGLDA TRAELIADPG AAANIHEIAA EGAFGRFRFQ 

       250        260        270 
IEGLPLPGNP RSSALTALSL LAALRQRGAA IRPSF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000031 Genomic DNA. Translation: AAV96121.1.
RefSeqYP_168088.1. NC_003911.12.

3D structure databases

ProteinModelPortalQ5LPG8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246200.SPO2880.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV96121; AAV96121; SPO2880.
GeneID3195767.
KEGGsil:SPO2880.
PATRIC23379185. VBIRuePom114501_2938.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1712.
HOGENOMHOG000206326.
KOK06989.
OMAECAGHSA.

Enzyme and pathway databases

UniPathwayUPA00253; UER00456.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01265. NadX.
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD_RUEPO
AccessionPrimary (citable) accession number: Q5LPG8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways