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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (deoA)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase

Enzyme and pathway databases

UniPathwayiUPA00578; UER00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotationImported
Ordered Locus Names:SPO2929Imported
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)Imported
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000001023 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi246200.SPO2929.

Structurei

3D structure databases

ProteinModelPortaliQ5LPB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini346 – 420PYNP_CInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CMW. Bacteria.
COG0213. LUCA.
HOGENOMiHOG000047313.
KOiK00758.
OMAiCGLAVPM.
OrthoDBiPOG091H02BC.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR017872. Pyrmidine_PPase_CS.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02644. Y_phosphoryl. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LPB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDARAIIARL RRHEVPSAAE LTWFAQGLAD GSVSDAQAGA FAMGVCMGRL
60 70 80 90 100
GSEGRAALTL AMRDTGDVLH WDFDGPVIDK HSTGGVGDCV SLVLAPALAE
110 120 130 140 150
CGTYVPMISG RGLGHTGGTL DKMEAIPGVT TQLGPDRLAQ VVRDTGAAIV
160 170 180 190 200
GATARIAPAD KRLYAIRDVT ATVESLDLIT ASILSKKLAA SPDALVLDVK
210 220 230 240 250
LGSGAFMKSP DEARALALAL TETANAAGCR TSALITDMSQ PLAPSLGNAL
260 270 280 290 300
EVGEVMRVLT SGHADDPLAQ LSAELGGVLL SDAGLATDAV SGAARIAAII
310 320 330 340 350
SDGRAAERFG RMIAAVGGPV QFVENWQRFL PEATVIREVP ARASGYVTAI
360 370 380 390 400
DGEVLGLAVV ALGGGRQVET DVVDPAVGLS RVIRLGTAVN PGTPLATIHA
410 420 430
ARQEAAEAAE ATLRAAITIG PEPVAAPPLI HERITP
Length:436
Mass (Da):44,550
Last modified:February 1, 2005 - v1
Checksum:i756D30DEEA4BC40D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV96170.1.
RefSeqiWP_011048629.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV96170; AAV96170; SPO2929.
KEGGisil:SPO2929.
PATRICi23379287. VBIRuePom114501_2989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV96170.1.
RefSeqiWP_011048629.1. NC_003911.12.

3D structure databases

ProteinModelPortaliQ5LPB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246200.SPO2929.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV96170; AAV96170; SPO2929.
KEGGisil:SPO2929.
PATRICi23379287. VBIRuePom114501_2989.

Phylogenomic databases

eggNOGiENOG4105CMW. Bacteria.
COG0213. LUCA.
HOGENOMiHOG000047313.
KOiK00758.
OMAiCGLAVPM.
OrthoDBiPOG091H02BC.

Enzyme and pathway databases

UniPathwayiUPA00578; UER00638.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR017872. Pyrmidine_PPase_CS.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02644. Y_phosphoryl. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5LPB9_RUEPO
AccessioniPrimary (citable) accession number: Q5LPB9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.