ID   Q5LP28_RUEPO            Unreviewed;       465 AA.
AC   Q5LP28;
DT   01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   01-FEB-2005, sequence version 1.
DT   24-JAN-2024, entry version 94.
DE   SubName: Full=Adenylate/guanylate cyclase/hydrolase, alpha/beta fold family {ECO:0000313|EMBL:AAV96260.1};
GN   OrderedLocusNames=SPO3024 {ECO:0000313|EMBL:AAV96260.1};
OS   Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter
OS   pomeroyi).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Ruegeria.
OX   NCBI_TaxID=246200 {ECO:0000313|EMBL:AAV96260.1, ECO:0000313|Proteomes:UP000001023};
RN   [1] {ECO:0000313|EMBL:AAV96260.1, ECO:0000313|Proteomes:UP000001023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700808 / DSM 15171 / DSS-3
RC   {ECO:0000313|Proteomes:UP000001023};
RX   PubMed=15602564; DOI=10.1038/nature03170;
RA   Moran M.A., Buchan A., Gonzalez J.M., Heidelberg J.F., Whitman W.B.,
RA   Kiene R.P., Henriksen J.R., King G.M., Belas R., Fuqua C., Brinkac L.,
RA   Lewis M., Johri S., Weaver B., Pai G., Eisen J.A., Rahe E., Sheldon W.M.,
RA   Ye W., Miller T.R., Carlton J., Rasko D.A., Paulsen I.T., Ren Q.,
RA   Daugherty S.C., Deboy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA   Nelson W.C., Sullivan S.A., Rosovitz M.J., Haft D.H., Selengut J., Ward N.;
RT   "Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine
RT   environment.";
RL   Nature 432:910-913(2004).
RN   [2] {ECO:0007829|PDB:3MR7}
RP   X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-187.
RA   Kim Y., Li H., Clancy S., Joachimiak A.;
RT   "Crystal Structure of Adenylate/Guanylate Cyclase/Hydrolase from
RT   Silicibacter pomeroyi.";
RL   Submitted (APR-2010) to the PDB data bank.
RN   [3] {ECO:0000313|EMBL:AAV96260.1, ECO:0000313|Proteomes:UP000001023}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 700808 / DSM 15171 / DSS-3
RC   {ECO:0000313|Proteomes:UP000001023};
RX   PubMed=25780504; DOI=10.1186/1944-3277-9-11;
RA   Rivers A.R., Smith C.B., Moran M.A.;
RT   "An updated genome annotation for the model marine bacterium Ruegeria
RT   pomeroyi DSS-3.";
RL   Stand. Genomic Sci. 9:11-11(2014).
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DR   EMBL; CP000031; AAV96260.1; -; Genomic_DNA.
DR   PDB; 3MR7; X-ray; 2.60 A; A/B/C=2-187.
DR   PDBsum; 3MR7; -.
DR   AlphaFoldDB; Q5LP28; -.
DR   SMR; Q5LP28; -.
DR   STRING; 246200.SPO3024; -.
DR   ESTHER; silpo-q5lp28; 6_AlphaBeta_hydrolase.
DR   PaxDb; 246200-SPO3024; -.
DR   DNASU; 3192818; -.
DR   KEGG; sil:SPO3024; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG2267; Bacteria.
DR   HOGENOM; CLU_589079_0_0_5; -.
DR   OrthoDB; 7267294at2; -.
DR   EvolutionaryTrace; Q5LP28; -.
DR   Proteomes; UP000001023; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43433:SF8; BLL8011 PROTEIN; 1.
DR   PANTHER; PTHR43433; HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3MR7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001023}.
FT   DOMAIN          7..122
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   465 AA;  51543 MW;  6964B207BC60278B CRC64;
     MERRLCAILA ADMAGYSRLM ERNETDVLNR QKLYRRELID PAIAQAGGQI VKTTGDGMLA
     RFDTAQAALR CALEIQQAMQ QREEDTPRKE RIQYRIGINI GDIVLEDGDI FGDAVNVAAR
     LEAISEPGAI CVSDIVHQIT QDRVSEPFTD LGLQKVKNIT RPIRVWQWVP DADRDQSHDP
     QPSHVQHVSF CIAGDGTQLA WARVGKGPSV LKAPNWLNHL DYEWRSPLWG PFLEQMSQRC
     DLVRFDQRGN GLSDRDPHEI SEDAMISDMR SIVQAAGLDR FLLFGISQGC AFSVRYAAEN
     PDKVAGLILV SGYLRGSLKR GSPEQAAISE ATNVLIREGW GSPNPAYRHL FTESMMPDAT
     EAQKAVFDEL QRVSCSPEVA ARINTMNATV DVSGFAPRIR VPTLVLHSEG DRRVPVAEGR
     RMAAMIPGAR FVTLPGNNHA LIDNSPALDL FLSEFSSFLA EIVES
//