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Protein

Formate--tetrahydrofolate ligase

Gene

fhs1

more
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhs1UniRule annotation
Synonyms:fhs-1
Ordered Locus Names:SPO1557
AND
Name:fhs2UniRule annotation
Synonyms:fhs-2
Ordered Locus Names:SPO3103
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_0000199374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO3103.

Structurei

3D structure databases

ProteinModelPortaliQ5LNV0.
SMRiQ5LNV0. Positions 6-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiMDMNDRQ.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LNV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYKSDIEIA REARKLPILE IGAKLGIAAD ELLPYGHDKA KVSQGFIDSV
60 70 80 90 100
QDRADGRLIL VTAINPTPAG EGKTTTTVGL GDGLNRIGKN AMICIREASL
110 120 130 140 150
GPNFGMKGGA AGGGYAQIVP MEEMNLHFTG DFHAITSAHS LLSAMIDNHI
160 170 180 190 200
YWGNEADIDT RRVVWRRVVD MNDRALRQIT CSLGGVSNGF PREAGFDITV
210 220 230 240 250
ASEVMAILCL ARDLKDLEKR LGDIIVAYRR DKSPVYCRDI KAEGAMTVLL
260 270 280 290 300
KDAMQPNLVQ TLENNPAFVH GGPFANIAHG CNSVIATKTA LKVADYVVTE
310 320 330 340 350
AGFGADLGAE KFMNIKCRKA GIAPSAVVLV ATVRAMKMNG GVAKGDLGAE
360 370 380 390 400
NVAAVNKGCA NLGRHIENVK SFGVPVVVAI NHFVTDTDAE VQAVRDYCAN
410 420 430 440 450
HGVEAVLSRH WELGSEGSEA LARKVVELAE SGKANFAPIY PDDMSLFEKI
460 470 480 490 500
ETIAKRIYRA DEVLADAKIR NQLKEWEEAG YRNLPVCMAK TQYSFTTDPN
510 520 530 540 550
RRGAPTGHSV PVREVRLSAG AGFIVVVCGE IMTMPGLPRK PAAETIRLND

AGQIEGLF
Length:558
Mass (Da):60,044
Last modified:February 1, 2005 - v1
Checksum:iFE0BD15E29A57DED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV94844.1.
CP000031 Genomic DNA. Translation: AAV96338.1.
RefSeqiWP_011047294.1. NC_003911.12.
YP_166798.1. NC_003911.12.
YP_168306.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV94844; AAV94844; SPO1557.
AAV96338; AAV96338; SPO3103.
KEGGisil:SPO1557.
sil:SPO3103.
PATRICi23376433. VBIRuePom114501_1581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV94844.1.
CP000031 Genomic DNA. Translation: AAV96338.1.
RefSeqiWP_011047294.1. NC_003911.12.
YP_166798.1. NC_003911.12.
YP_168306.1. NC_003911.12.

3D structure databases

ProteinModelPortaliQ5LNV0.
SMRiQ5LNV0. Positions 6-556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246200.SPO3103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV94844; AAV94844; SPO1557.
AAV96338; AAV96338; SPO3103.
KEGGisil:SPO1557.
sil:SPO3103.
PATRICi23376433. VBIRuePom114501_1581.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiMDMNDRQ.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiFTHS_RUEPO
AccessioniPrimary (citable) accession number: Q5LNV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 1, 2005
Last modified: May 27, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.