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Q5LNV0 (FTHS_RUEPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs1
Synonyms:fhs-1
Ordered Locus Names:SPO1557
AND
Name:fhs2
Synonyms:fhs-2
Ordered Locus Names:SPO3103
OrganismRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) [Complete proteome] [HAMAP]
Taxonomic identifier246200 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199374

Regions

Nucleotide binding67 – 748ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5LNV0 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: FE0BD15E29A57DED

FASTA55860,044
        10         20         30         40         50         60 
MAYKSDIEIA REARKLPILE IGAKLGIAAD ELLPYGHDKA KVSQGFIDSV QDRADGRLIL 

        70         80         90        100        110        120 
VTAINPTPAG EGKTTTTVGL GDGLNRIGKN AMICIREASL GPNFGMKGGA AGGGYAQIVP 

       130        140        150        160        170        180 
MEEMNLHFTG DFHAITSAHS LLSAMIDNHI YWGNEADIDT RRVVWRRVVD MNDRALRQIT 

       190        200        210        220        230        240 
CSLGGVSNGF PREAGFDITV ASEVMAILCL ARDLKDLEKR LGDIIVAYRR DKSPVYCRDI 

       250        260        270        280        290        300 
KAEGAMTVLL KDAMQPNLVQ TLENNPAFVH GGPFANIAHG CNSVIATKTA LKVADYVVTE 

       310        320        330        340        350        360 
AGFGADLGAE KFMNIKCRKA GIAPSAVVLV ATVRAMKMNG GVAKGDLGAE NVAAVNKGCA 

       370        380        390        400        410        420 
NLGRHIENVK SFGVPVVVAI NHFVTDTDAE VQAVRDYCAN HGVEAVLSRH WELGSEGSEA 

       430        440        450        460        470        480 
LARKVVELAE SGKANFAPIY PDDMSLFEKI ETIAKRIYRA DEVLADAKIR NQLKEWEEAG 

       490        500        510        520        530        540 
YRNLPVCMAK TQYSFTTDPN RRGAPTGHSV PVREVRLSAG AGFIVVVCGE IMTMPGLPRK 

       550 
PAAETIRLND AGQIEGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000031 Genomic DNA. Translation: AAV94844.1.
CP000031 Genomic DNA. Translation: AAV96338.1.
RefSeqYP_166798.1. NC_003911.12.
YP_168306.1. NC_003911.12.

3D structure databases

ProteinModelPortalQ5LNV0.
SMRQ5LNV0. Positions 6-556.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246200.SPO3103.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV94844; AAV94844; SPO1557.
AAV96338; AAV96338; SPO3103.
GeneID3194762.
3195304.
KEGGsil:SPO1557.
sil:SPO3103.
PATRIC23376433. VBIRuePom114501_1581.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAACEEETE.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_RUEPO
AccessionPrimary (citable) accession number: Q5LNV0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways