SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5LNV0

- FTHS_RUEPO

UniProt

Q5LNV0 - FTHS_RUEPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Formate--tetrahydrofolate ligase
Gene
fhs1, fhs-1, SPO1557
fhs2, fhs-2, SPO3103
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs1
Synonyms:fhs-1
Ordered Locus Names:SPO1557
AND
Name:fhs2
Synonyms:fhs-2
Ordered Locus Names:SPO3103
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO3103.

Structurei

3D structure databases

ProteinModelPortaliQ5LNV0.
SMRiQ5LNV0. Positions 6-556.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiACEEETE.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LNV0-1 [UniParc]FASTAAdd to Basket

« Hide

MAYKSDIEIA REARKLPILE IGAKLGIAAD ELLPYGHDKA KVSQGFIDSV    50
QDRADGRLIL VTAINPTPAG EGKTTTTVGL GDGLNRIGKN AMICIREASL 100
GPNFGMKGGA AGGGYAQIVP MEEMNLHFTG DFHAITSAHS LLSAMIDNHI 150
YWGNEADIDT RRVVWRRVVD MNDRALRQIT CSLGGVSNGF PREAGFDITV 200
ASEVMAILCL ARDLKDLEKR LGDIIVAYRR DKSPVYCRDI KAEGAMTVLL 250
KDAMQPNLVQ TLENNPAFVH GGPFANIAHG CNSVIATKTA LKVADYVVTE 300
AGFGADLGAE KFMNIKCRKA GIAPSAVVLV ATVRAMKMNG GVAKGDLGAE 350
NVAAVNKGCA NLGRHIENVK SFGVPVVVAI NHFVTDTDAE VQAVRDYCAN 400
HGVEAVLSRH WELGSEGSEA LARKVVELAE SGKANFAPIY PDDMSLFEKI 450
ETIAKRIYRA DEVLADAKIR NQLKEWEEAG YRNLPVCMAK TQYSFTTDPN 500
RRGAPTGHSV PVREVRLSAG AGFIVVVCGE IMTMPGLPRK PAAETIRLND 550
AGQIEGLF 558
Length:558
Mass (Da):60,044
Last modified:February 1, 2005 - v1
Checksum:iFE0BD15E29A57DED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV94844.1.
CP000031 Genomic DNA. Translation: AAV96338.1.
RefSeqiYP_166798.1. NC_003911.12.
YP_168306.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV94844; AAV94844; SPO1557.
AAV96338; AAV96338; SPO3103.
GeneIDi3194762.
3195304.
KEGGisil:SPO1557.
sil:SPO3103.
PATRICi23376433. VBIRuePom114501_1581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV94844.1 .
CP000031 Genomic DNA. Translation: AAV96338.1 .
RefSeqi YP_166798.1. NC_003911.12.
YP_168306.1. NC_003911.12.

3D structure databases

ProteinModelPortali Q5LNV0.
SMRi Q5LNV0. Positions 6-556.
ModBasei Search...

Protein-protein interaction databases

STRINGi 246200.SPO3103.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV94844 ; AAV94844 ; SPO1557 .
AAV96338 ; AAV96338 ; SPO3103 .
GeneIDi 3194762.
3195304.
KEGGi sil:SPO1557.
sil:SPO3103.
PATRICi 23376433. VBIRuePom114501_1581.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi ACEEETE.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiFTHS_RUEPO
AccessioniPrimary (citable) accession number: Q5LNV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi