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Q5LNJ7 (ISPH_SILPO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
EC=1.17.1.2
Gene names
Name:ispH
Ordered Locus Names:SPO3207
OrganismSilicibacter pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) [Complete proteome] [HAMAP]
Taxonomic identifier246200 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Ruegeria

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3163164-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
PRO_0000128873

Sequences

Sequence LengthMass (Da)Tools
Q5LNJ7 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: F7DDB306BE4991A7

FASTA31634,351
        10         20         30         40         50         60 
MTKSPLTLYL AAPRGFCAGV DRAIKIVEMA IEKWGAPVYV RHEIVHNKFV VDGLRAKGAV 

        70         80         90        100        110        120 
FVEELDECPD DRPVIFSAHG VPKAIPAEAE RRQMVYVDAT CPLVSKVHIE AERHAEHGLQ 

       130        140        150        160        170        180 
IIMIGHRGHP ETIGTMGQLP EGEVLLVETV ADVARIAVRD PARLAFVTQT TLSVDDTRDI 

       190        200        210        220        230        240 
VAALQARFPQ IVGPHKEDIC YATTNRQEAV KAVAPKSDAL LVVGAPNSSN SRRLVEVAAK 

       250        260        270        280        290        300 
AGCSYAQLVQ RADDIDWRAL DGIATIAVSA GASAPELLVN EVIDAFRARF DVTVEVVETA 

       310 
VEHVEFKVPR VLRQPA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000031 Genomic DNA. Translation: AAV96442.1.
RefSeqYP_168410.1. NC_003911.11.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3195859.
GenomeReviewsGene locus SPO3207 in contig CP000031_GR.
KEGGsil:SPO3207.
NMPDRfig|246200.3.peg.3580.
PATRIC23379861. VBIRuePom114501_3274.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG335228.
OMAWGAPVYV.
ProtClustDBPRK01045.

Enzyme and pathway databases

BioCycRPOM246200:SPO_3207-MONOMER.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameISPH_SILPO
AccessionPrimary (citable) accession number: Q5LNJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 1, 2005
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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