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Q5LN38 (PUR9_RUEPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:SPO3374
OrganismRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) [Complete proteome] [HAMAP]
Taxonomic identifier246200 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000057914

Sequences

Sequence LengthMass (Da)Tools
Q5LN38 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 84C98089A17E5D02

FASTA52955,777
        10         20         30         40         50         60 
MTDLSPVRRA LLSVSDKTGL IELGQALAAR GVELLSTGGT AKALRDAGLT VRDVAEVTGF 

        70         80         90        100        110        120 
PEMMDGRVKT LHPMVHGGLL ALRDNADHVA AMEQHGIAGI DLLVVNLYPF EATVAKGADY 

       130        140        150        160        170        180 
DDCIENIDIG GPAMIRAASK NHAFVNVVVD VADYDALLAE MAANDGQTSY AFRQRLAQTA 

       190        200        210        220        230        240 
YARTAAYDAA VSNWMADQLA LEAPRRRAFA GELKQTLRYG ENSHQQAAFY TDGSNRPGVA 

       250        260        270        280        290        300 
TARQLQGKEL SYNNINDTDA AFELVAEFAP ENGPACAIIK HANPCGVALG ATLSEAYQKA 

       310        320        330        340        350        360 
FDCDRTSAFG GIVALNQPLD AETAGKIVEI FTEVVIAPGA SDEAIAIFAT KKNLRLLLTD 

       370        380        390        400        410        420 
GLPDPRQPIV AMKQVAGGLL VQDKDVGHVD LTDLKVVTRK APTEAQMADL LFAWKVGKHV 

       430        440        450        460        470        480 
KSNAIVYVKD GATVGVGAGQ MSRLDSANVA AAKAQRMATE LGLPESPAKG CAVASDAFFP 

       490        500        510        520 
FADGLLEAAA AGGACVIQPG GSMRDDEVIK AADEAGLAMV FTGMRHFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000031 Genomic DNA. Translation: AAV96601.1.
RefSeqYP_168570.1. NC_003911.12.

3D structure databases

ProteinModelPortalQ5LN38.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246200.SPO3374.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV96601; AAV96601; SPO3374.
GeneID3195268.
KEGGsil:SPO3374.
PATRIC23380201. VBIRuePom114501_3437.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230372.
KOK00602.
OMACGVATGP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_RUEPO
AccessionPrimary (citable) accession number: Q5LN38
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways