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Q5LN38

- PUR9_RUEPO

UniProt

Q5LN38 - PUR9_RUEPO

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, SPO3374
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:SPO3374
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000057914Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO3374.

Structurei

3D structure databases

ProteinModelPortaliQ5LN38.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5LN38-1 [UniParc]FASTAAdd to Basket

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MTDLSPVRRA LLSVSDKTGL IELGQALAAR GVELLSTGGT AKALRDAGLT    50
VRDVAEVTGF PEMMDGRVKT LHPMVHGGLL ALRDNADHVA AMEQHGIAGI 100
DLLVVNLYPF EATVAKGADY DDCIENIDIG GPAMIRAASK NHAFVNVVVD 150
VADYDALLAE MAANDGQTSY AFRQRLAQTA YARTAAYDAA VSNWMADQLA 200
LEAPRRRAFA GELKQTLRYG ENSHQQAAFY TDGSNRPGVA TARQLQGKEL 250
SYNNINDTDA AFELVAEFAP ENGPACAIIK HANPCGVALG ATLSEAYQKA 300
FDCDRTSAFG GIVALNQPLD AETAGKIVEI FTEVVIAPGA SDEAIAIFAT 350
KKNLRLLLTD GLPDPRQPIV AMKQVAGGLL VQDKDVGHVD LTDLKVVTRK 400
APTEAQMADL LFAWKVGKHV KSNAIVYVKD GATVGVGAGQ MSRLDSANVA 450
AAKAQRMATE LGLPESPAKG CAVASDAFFP FADGLLEAAA AGGACVIQPG 500
GSMRDDEVIK AADEAGLAMV FTGMRHFRH 529
Length:529
Mass (Da):55,777
Last modified:February 1, 2005 - v1
Checksum:i84C98089A17E5D02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV96601.1.
RefSeqiYP_168570.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV96601; AAV96601; SPO3374.
GeneIDi3195268.
KEGGisil:SPO3374.
PATRICi23380201. VBIRuePom114501_3437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000031 Genomic DNA. Translation: AAV96601.1 .
RefSeqi YP_168570.1. NC_003911.12.

3D structure databases

ProteinModelPortali Q5LN38.
ModBasei Search...

Protein-protein interaction databases

STRINGi 246200.SPO3374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV96601 ; AAV96601 ; SPO3374 .
GeneIDi 3195268.
KEGGi sil:SPO3374.
PATRICi 23380201. VBIRuePom114501_3437.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiPUR9_RUEPO
AccessioniPrimary (citable) accession number: Q5LN38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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