Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5LMY0

- SYL_RUEPO

UniProt

Q5LMY0 - SYL_RUEPO

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei626 – 6261ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:SPO3432
    OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
    Taxonomic identifieri246200 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
    ProteomesiUP000001023: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 852852Leucine--tRNA ligasePRO_0000152081Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246200.SPO3432.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5LMY0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionAdd
    BLAST
    Motifi623 – 6275"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5LMY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRYSATEIE AKWQEAWDKA GIFRAARTAD KPKYYVLEMF PYPSGRIHIG    50
    HVRNYTMGDV IARYKLSNGF NVLHPMGFDA FGMPAENAAM ASGGHPKDWT 100
    YKNIETMVAQ MKPLGFGLDW SRMFATCDPE YYGQQQALFL DFLEKGLVYR 150
    KNAVVNWDPV DMTVLANEQV EDGRGWRSGA LVERRELTQW FFKISDMSGE 200
    LLDALDTLDD WPAKVKLMQA NWIGKSRGLQ FSWALTEPAH GIEALDVYTT 250
    RPDTLMGASF LGISPDHPLT KALEAENPDL AAKVAEMRKG GTTEEAIEKA 300
    EKLGADTGLR VRHPLNPDWE LPVWVANFIL MDYGTGAIFA CPAHDQRDLD 350
    FCRKYDLPVI DTFVALDDPK PIATEAFVPL KTEKVKWIDH FAGLDVATGQ 400
    EAIDTTIDWM EAKGLGTGVT KFRLRDWGLS RQRYWGCPIP VVHCDACGVV 450
    PEKKENLPIR LPDDVTFDVP GNPLDRHPTW RDCACPSCGK PARRETDTMD 500
    TFVDSSWYFA RFTAPRAETP TDMAEAEYWM NVDQYIGGIE HAILHLLYSR 550
    FFARAMHICG HLPEKSKEPF NALFTQGMVT HAIYKTTGAD DRPVYHYPEA 600
    VRLEGGKGYL EDGTEVEIIP SAKMSKSKNN VVDPVAIIDR FGADTARWFV 650
    LSDSPPERDV EWTDAGAEAA HKHLNRVWNL CDRIAAMDSA APGEGDDDLL 700
    REMHKCIRDV TNGIESFGFN ASIAKLYAFT NTLAKSKAGA AAQKQAIMTL 750
    AQLMSPMTPH LAEDIWAHQG GEGLIAAAPW PVADEAMLVD ALVTLPVQIN 800
    GKRRAEISVP ADMDKTQVEK LALSTDAVQK ALDGAAPKKV IVVPGRIVNV 850
    VV 852
    Length:852
    Mass (Da):94,818
    Last modified:February 1, 2005 - v1
    Checksum:i52EB8247D0D84839
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000031 Genomic DNA. Translation: AAV96658.1.
    RefSeqiYP_168628.1. NC_003911.12.

    Genome annotation databases

    EnsemblBacteriaiAAV96658; AAV96658; SPO3432.
    GeneIDi3192670.
    KEGGisil:SPO3432.
    PATRICi23380325. VBIRuePom114501_3499.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000031 Genomic DNA. Translation: AAV96658.1 .
    RefSeqi YP_168628.1. NC_003911.12.

    3D structure databases

    ProteinModelPortali Q5LMY0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246200.SPO3432.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV96658 ; AAV96658 ; SPO3432 .
    GeneIDi 3192670.
    KEGGi sil:SPO3432.
    PATRICi 23380325. VBIRuePom114501_3499.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700808 / DSM 15171 / DSS-3.

    Entry informationi

    Entry nameiSYL_RUEPO
    AccessioniPrimary (citable) accession number: Q5LMY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3