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Q5LMY0

- SYL_RUEPO

UniProt

Q5LMY0 - SYL_RUEPO

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei626 – 6261ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SPO3432
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 852852Leucine--tRNA ligasePRO_0000152081Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPO3432.

Structurei

3D structure databases

ProteinModelPortaliQ5LMY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionAdd
BLAST
Motifi623 – 6275"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LMY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRYSATEIE AKWQEAWDKA GIFRAARTAD KPKYYVLEMF PYPSGRIHIG
60 70 80 90 100
HVRNYTMGDV IARYKLSNGF NVLHPMGFDA FGMPAENAAM ASGGHPKDWT
110 120 130 140 150
YKNIETMVAQ MKPLGFGLDW SRMFATCDPE YYGQQQALFL DFLEKGLVYR
160 170 180 190 200
KNAVVNWDPV DMTVLANEQV EDGRGWRSGA LVERRELTQW FFKISDMSGE
210 220 230 240 250
LLDALDTLDD WPAKVKLMQA NWIGKSRGLQ FSWALTEPAH GIEALDVYTT
260 270 280 290 300
RPDTLMGASF LGISPDHPLT KALEAENPDL AAKVAEMRKG GTTEEAIEKA
310 320 330 340 350
EKLGADTGLR VRHPLNPDWE LPVWVANFIL MDYGTGAIFA CPAHDQRDLD
360 370 380 390 400
FCRKYDLPVI DTFVALDDPK PIATEAFVPL KTEKVKWIDH FAGLDVATGQ
410 420 430 440 450
EAIDTTIDWM EAKGLGTGVT KFRLRDWGLS RQRYWGCPIP VVHCDACGVV
460 470 480 490 500
PEKKENLPIR LPDDVTFDVP GNPLDRHPTW RDCACPSCGK PARRETDTMD
510 520 530 540 550
TFVDSSWYFA RFTAPRAETP TDMAEAEYWM NVDQYIGGIE HAILHLLYSR
560 570 580 590 600
FFARAMHICG HLPEKSKEPF NALFTQGMVT HAIYKTTGAD DRPVYHYPEA
610 620 630 640 650
VRLEGGKGYL EDGTEVEIIP SAKMSKSKNN VVDPVAIIDR FGADTARWFV
660 670 680 690 700
LSDSPPERDV EWTDAGAEAA HKHLNRVWNL CDRIAAMDSA APGEGDDDLL
710 720 730 740 750
REMHKCIRDV TNGIESFGFN ASIAKLYAFT NTLAKSKAGA AAQKQAIMTL
760 770 780 790 800
AQLMSPMTPH LAEDIWAHQG GEGLIAAAPW PVADEAMLVD ALVTLPVQIN
810 820 830 840 850
GKRRAEISVP ADMDKTQVEK LALSTDAVQK ALDGAAPKKV IVVPGRIVNV

VV
Length:852
Mass (Da):94,818
Last modified:February 1, 2005 - v1
Checksum:i52EB8247D0D84839
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV96658.1.
RefSeqiWP_011049115.1. NC_003911.12.
YP_168628.1. NC_003911.12.

Genome annotation databases

EnsemblBacteriaiAAV96658; AAV96658; SPO3432.
GeneIDi3192670.
KEGGisil:SPO3432.
PATRICi23380325. VBIRuePom114501_3499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000031 Genomic DNA. Translation: AAV96658.1 .
RefSeqi WP_011049115.1. NC_003911.12.
YP_168628.1. NC_003911.12.

3D structure databases

ProteinModelPortali Q5LMY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246200.SPO3432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV96658 ; AAV96658 ; SPO3432 .
GeneIDi 3192670.
KEGGi sil:SPO3432.
PATRICi 23380325. VBIRuePom114501_3499.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiSYL_RUEPO
AccessioniPrimary (citable) accession number: Q5LMY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3