ID   Q5LMB3_RUEPO            Unreviewed;       590 AA.
AC   Q5LMB3;
DT   01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   01-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AAV96873.1};
GN   OrderedLocusNames=SPO3650 {ECO:0000313|EMBL:AAV96873.1};
OS   Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter
OS   pomeroyi).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Ruegeria.
OX   NCBI_TaxID=246200 {ECO:0000313|EMBL:AAV96873.1, ECO:0000313|Proteomes:UP000001023};
RN   [1] {ECO:0000313|EMBL:AAV96873.1, ECO:0000313|Proteomes:UP000001023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700808 / DSM 15171 / DSS-3
RC   {ECO:0000313|Proteomes:UP000001023};
RX   PubMed=15602564; DOI=10.1038/nature03170;
RA   Moran M.A., Buchan A., Gonzalez J.M., Heidelberg J.F., Whitman W.B.,
RA   Kiene R.P., Henriksen J.R., King G.M., Belas R., Fuqua C., Brinkac L.,
RA   Lewis M., Johri S., Weaver B., Pai G., Eisen J.A., Rahe E., Sheldon W.M.,
RA   Ye W., Miller T.R., Carlton J., Rasko D.A., Paulsen I.T., Ren Q.,
RA   Daugherty S.C., Deboy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA   Nelson W.C., Sullivan S.A., Rosovitz M.J., Haft D.H., Selengut J., Ward N.;
RT   "Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine
RT   environment.";
RL   Nature 432:910-913(2004).
RN   [2] {ECO:0000313|EMBL:AAV96873.1, ECO:0000313|Proteomes:UP000001023}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 700808 / DSM 15171 / DSS-3
RC   {ECO:0000313|Proteomes:UP000001023};
RX   PubMed=25780504; DOI=10.1186/1944-3277-9-11;
RA   Rivers A.R., Smith C.B., Moran M.A.;
RT   "An updated genome annotation for the model marine bacterium Ruegeria
RT   pomeroyi DSS-3.";
RL   Stand. Genomic Sci. 9:11-11(2014).
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DR   EMBL; CP000031; AAV96873.1; -; Genomic_DNA.
DR   RefSeq; WP_011049330.1; NC_003911.12.
DR   AlphaFoldDB; Q5LMB3; -.
DR   STRING; 246200.SPO3650; -.
DR   PaxDb; 246200-SPO3650; -.
DR   KEGG; sil:SPO3650; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG5616; Bacteria.
DR   HOGENOM; CLU_019981_0_0_5; -.
DR   OrthoDB; 54411at2; -.
DR   Proteomes; UP000001023; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.40.50.10610; ABC-type transport auxiliary lipoprotein component; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001023};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          7..122
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          411..444
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   590 AA;  65313 MW;  106CAED2B719CB5B CRC64;
     MERRLTTILA ADLSGYSRLM AADEEGTVTR LRHLFADIVR PDLSREGGRL IKTMGDGMLV
     EFASPVAALR SAVAILQQVA RDQVETAPDT RMLFRVGIHL GDVISDGDDI LGDAVNIAAR
     LESLATPGGI CISRSVHDQV RGKVDAELIE LGPQPVKNIP DPVEVWRVGA EGIACAAEKP
     AVRAELPAVV ILPFDNMSAD PEQDFLADGI VEDVTTELSR FRTLTVIARN SAFAYKGSHK
     DVRQIAEELG VRYVVEGSVR RAGDRLRATA QLIDARTGAH VWADRWDRTM ADLFDLQDEL
     TAAILSGVEP ELGAHERNLA RRKPTDSLTA WEMCQKGYSE FTRYTDEGYS QAHAYYTRAI
     AADPDFALPH ALLARLAWVK VITGRTRDPA AEISTGLDHA AQAIERDDRL EIGYVALGVL
     LAITGREQDA ADALDKAEAL NPNNAVLHFG RCHACLFMQR LDCDRLERAA RTALRLNPKD
     PMAWGFWFQL GNAFTFRDID AAEPEALAAY ETACRFANAD YFVFMATALK HAKLGNRDKA
     AHYLAQARER YPALTAEFWR RAFRFPIWSR WVAADEPNIQ LLIDLGLPQK
//