Histidinol dehydrogenase 3 - Silicibacter pomeroyi

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Reviewed, UniProtKB/Swiss-Prot Q5LL27 (HISX3_SILPO)

Last modified November 3, 2009. Version 36. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase 3
      Short name=HDH 3
    EC=1.1.1.23

Gene names

Name:	hisD3
Ordered Locus Names:	SPOA0202

Encoded on

Plasmid megaplasmid Spo

Organism

Silicibacter pomeroyi [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Ruegeria

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD⁺ = L-histidine + 2 NADH. HAMAP MF_01024
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

433

Histidinol dehydrogenase 3 HAMAP MF_01024

PRO_0000135848

Sites

Active site

1

Proton acceptor By similarity

Active site

1

Proton acceptor By similarity

Metal binding

1

Zinc By similarity

Metal binding

1

Zinc By similarity

Metal binding

1

Zinc By similarity

Metal binding

1

Zinc By similarity

Binding site

1

NAD By similarity

Binding site

1

NAD By similarity

Binding site

1

NAD By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q5LL27-1 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: C15B11CCF2ACC563
Show »

433

45,887

        10         20         30         40         50         60 
MPQFLDSRQP DFETAFTALL GAKREDSPDV DAVVAGIIAD VRARGDAAVI ELTERFDRVA 

        70         80         90        100        110        120 
LTPQSLRFST EEIAQAVDEV PAPERAALEL AAARIRAYHE RQMPQDADWT DDTGARLGWR 

       130        140        150        160        170        180 
WSAVSAAGLY VPGGLASYPS SVLMNAIPAK VAGVGRLAIA VPTPDGQVNP LVLLAAQISG 

       190        200        210        220        230        240 
VDEVYRIGGA QAIAALAYGT DTIAPVDKIT GPGNAFVAAA KRRVFGKVGI DMIAGPSEIL 

       250        260        270        280        290        300 
VIADRDNDPD WIALDLLSQA EHDESAQSIL ITDDAAFGRA VAEAVDKRLE TLERRAIAGV 

       310        320        330        340        350        360 
SWRDFGAVIT VSDLDEAAAL SNRIAPEHLE LCVSDPEALA ARTIHAGAIF LGQYTPEAIG 

       370        380        390        400        410        420 
DYVGGPNHVL PTARSARFSS GLSVMDFLKR TTMSRMTPEA LRAIGPAAAQ LARSESLEAH 

       430 
GLSVQARLDR LNG

Cross-references

Sequence databases
	CP000032 Genomic DNA. Translation: AAV97336.1.
RefSeq	YP_165031.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3196717.
GenomeReviews	Gene locus SPOA0202 in contig CP000032_GR.
KEGG	sil:SPOA0202.
NMPDR	fig\|246200.3.peg.68.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5LL27.
OMA	LDAHKNA.
Enzyme and pathway databases
BioCyc	SPOM246200:SPO_A0202-MON.
BRENDA	1.1.1.23. 278247.
Family and domain databases
HAMAP	MF_01024. [Tree]
InterPro	IPR001692. Histidinol_DH_CS. IPR012131. Hstdl_DH_prok-type. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX3_SILPO

Accession

Primary (citable) accession number: Q5LL27

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	February 1, 2005
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents