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Q5LL27

- HISX3_RUEPO

UniProt

Q5LL27 - HISX3_RUEPO

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Protein

Histidinol dehydrogenase 3

Gene
hisD3, SPOA0202
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NAD By similarity
Binding sitei191 – 1911NAD By similarity
Binding sitei214 – 2141NAD By similarity
Binding sitei237 – 2371Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Active sitei327 – 3271Proton acceptor By similarity
Active sitei328 – 3281Proton acceptor By similarity
Binding sitei328 – 3281Substrate By similarity
Metal bindingi361 – 3611Zinc By similarity
Binding sitei361 – 3611Substrate By similarity
Binding sitei415 – 4151Substrate By similarity
Metal bindingi420 – 4201Zinc By similarity
Binding sitei420 – 4201Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 3 (EC:1.1.1.23)
Short name:
HDH 3
Gene namesi
Name:hisD3
Ordered Locus Names:SPOA0202
Encoded oniPlasmid megaplasmid Spo0 Publication
OrganismiRuegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Taxonomic identifieri246200 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000001023: Plasmid megaplasmid Spo

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Histidinol dehydrogenase 3UniRule annotationPRO_0000135848Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246200.SPOA0202.

Structurei

3D structure databases

ProteinModelPortaliQ5LL27.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiCAIANRI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LL27-1 [UniParc]FASTAAdd to Basket

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MPQFLDSRQP DFETAFTALL GAKREDSPDV DAVVAGIIAD VRARGDAAVI    50
ELTERFDRVA LTPQSLRFST EEIAQAVDEV PAPERAALEL AAARIRAYHE 100
RQMPQDADWT DDTGARLGWR WSAVSAAGLY VPGGLASYPS SVLMNAIPAK 150
VAGVGRLAIA VPTPDGQVNP LVLLAAQISG VDEVYRIGGA QAIAALAYGT 200
DTIAPVDKIT GPGNAFVAAA KRRVFGKVGI DMIAGPSEIL VIADRDNDPD 250
WIALDLLSQA EHDESAQSIL ITDDAAFGRA VAEAVDKRLE TLERRAIAGV 300
SWRDFGAVIT VSDLDEAAAL SNRIAPEHLE LCVSDPEALA ARTIHAGAIF 350
LGQYTPEAIG DYVGGPNHVL PTARSARFSS GLSVMDFLKR TTMSRMTPEA 400
LRAIGPAAAQ LARSESLEAH GLSVQARLDR LNG 433
Length:433
Mass (Da):45,887
Last modified:February 1, 2005 - v1
Checksum:iC15B11CCF2ACC563
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000032 Genomic DNA. Translation: AAV97336.1.
RefSeqiYP_165031.1. NC_006569.1.

Genome annotation databases

EnsemblBacteriaiAAV97336; AAV97336; SPOA0202.
GeneIDi3196717.
KEGGisil:SPOA0202.
PATRICi23381738. VBIRuePom114501_4192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000032 Genomic DNA. Translation: AAV97336.1 .
RefSeqi YP_165031.1. NC_006569.1.

3D structure databases

ProteinModelPortali Q5LL27.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246200.SPOA0202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV97336 ; AAV97336 ; SPOA0202 .
GeneIDi 3196717.
KEGGi sil:SPOA0202.
PATRICi 23381738. VBIRuePom114501_4192.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi CAIANRI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700808 / DSM 15171 / DSS-3.

Entry informationi

Entry nameiHISX3_RUEPO
AccessioniPrimary (citable) accession number: Q5LL27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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