Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

UCHL5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
Gene namesi
Name:UCHL5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116750.13
HGNCiHGNC:19678 UCHL5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000116750

PTM / Processingi

Proteomic databases

MaxQBiQ5LJB0
PeptideAtlasiQ5LJB0
PRIDEiQ5LJB0

Expressioni

Gene expression databases

BgeeiENSG00000116750
ExpressionAtlasiQ5LJB0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5LJB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 200UCH_1InterPro annotationAdd BLAST189

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili212 – 232Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase C12 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2778 Eukaryota
ENOG410XP0P LUCA
GeneTreeiENSGT00510000046560
HOGENOMiHOG000203918
HOVERGENiHBG056021

Family and domain databases

CDDicd02255 Peptidase_C12, 1 hit
Gene3Di3.40.532.10, 1 hit
InterProiView protein in InterPro
IPR001578 Peptidase_C12_UCH
IPR036959 Peptidase_C12_UCH_sf
IPR033837 UCH37
PANTHERiPTHR10589 PTHR10589, 1 hit
PfamiView protein in Pfam
PF01088 Peptidase_C12, 1 hit
PRINTSiPR00707 UBCTHYDRLASE

Sequencei

Sequence statusi: Fragment.

Q5LJB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGWLERPP ALSRAAGCRG AQVEEIWSLE PENFEKLKPV HGLIFLFKWQ
60 70 80 90 100
PGEEPAGSVV QDSRLDTIFF AKQVINNACA TQAIVSVLLN CTHQDVHLGE
110 120 130 140 150
TLSEFKEFSQ SFDAAMKGLA LSNSDVIRQV HNSFARQQMF EFDTKTSAKE
160 170 180 190 200
EDAFHFVSYV PVNGRLYELD GLREGPIDLG ACNQDDWISA VRPVIEKRIQ
210 220 230 240 250
KYSEGEIRFN LMAIVSDRKM IYEQKIAELQ RQLAEEPMDT DQGNSMLSAI

QSEVAKNQ
Length:258
Mass (Da):29,116
Last modified:February 1, 2005 - v1
Checksum:i0C755C6037C63C97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei258Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136370 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000421683; ENSP00000389563; ENSG00000116750
UCSCiuc057obm.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5LJB0_HUMAN
AccessioniPrimary (citable) accession number: Q5LJB0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health