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Q5LJ30

- UPPP_BACFN

UniProt

Q5LJ30 - UPPP_BACFN

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBFRA272559:GKF0-67-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:BF0068
    OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
    Taxonomic identifieri272559 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000006731: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Undecaprenyl-diphosphatasePRO_0000227605Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272559.BF0068.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121HelicalUniRule annotationAdd
    BLAST
    Transmembranei82 – 10221HelicalUniRule annotationAdd
    BLAST
    Transmembranei106 – 12621HelicalUniRule annotationAdd
    BLAST
    Transmembranei140 – 16021HelicalUniRule annotationAdd
    BLAST
    Transmembranei180 – 20021HelicalUniRule annotationAdd
    BLAST
    Transmembranei213 – 23321HelicalUniRule annotationAdd
    BLAST
    Transmembranei245 – 26521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    KOiK06153.
    OMAiMENIGWK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5LJ30-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEWFEALILG LIQGLTEYLP VSSSGHLAIG SALFGIEGEE NLAFTIVVHV    50
    ATVFSTLVIL WKEIDWIFRG LFKFEMNSET RYVINILISM IPIGIVGVFF 100
    KDEVEAIFGS GLLIVGCMLL LTAALLSFSY YAKPRQKENI SMKDAFIIGL 150
    AQACAVLPGL SRSGSTIATG LLLGDNKAKL AQFSFLMVIP PILGEALLDG 200
    MKMIKGEAIA GDIPTLSLIV GFIAAFVSGC LACKWMINIV KKGKLIYFAI 250
    YCAIVGVVTI VVSQLQ 266
    Length:266
    Mass (Da):28,752
    Last modified:June 21, 2005 - v1
    Checksum:i06A5F948C9F99616
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR626927 Genomic DNA. Translation: CAH05846.1.
    RefSeqiYP_209808.1. NC_003228.3.

    Genome annotation databases

    EnsemblBacteriaiCAH05846; CAH05846; BF9343_0067.
    GeneIDi3288204.
    KEGGibfs:BF0068.
    PATRICi21036596. VBIBacFra29119_0065.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR626927 Genomic DNA. Translation: CAH05846.1 .
    RefSeqi YP_209808.1. NC_003228.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272559.BF0068.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH05846 ; CAH05846 ; BF9343_0067 .
    GeneIDi 3288204.
    KEGGi bfs:BF0068.
    PATRICi 21036596. VBIBacFra29119_0065.

    Phylogenomic databases

    eggNOGi COG1968.
    KOi K06153.
    OMAi MENIGWK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci BFRA272559:GKF0-67-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25285 / NCTC 9343.

    Entry informationi

    Entry nameiUPPP_BACFN
    AccessioniPrimary (citable) accession number: Q5LJ30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3