Q5LIV6 (UXUA_BACFN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	BF0142

Organism

Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]

Taxonomic identifier

272559 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Mannonate dehydratase HAMAP MF_00106		PRO_0000231051

Sequences

	Sequence		Length	Mass (Da)
	Q5LIV6 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: A9CFFC18C463DD8F	FASTA	396	45,341
	10 20 30 40 50 60 MTLPKDKLFL SEQTWRWYGP DDPVSLWDIK QAGATGIVNA LHHIPNGEVW TVEEIMKRKE 70 80 90 100 110 120 LIESVGLKWS VVESVPVHEH IKTQTGNFRK YIENYKESLR NLGQCGIHIV TYNFMPVLDW 130 140 150 160 170 180 TRTDLAYTLP DGSKALRFER AAFIAFDLFL LKRPGAETEY TDEEKTKARI RFEQMDEKEK 190 200 210 220 230 240 QLLVRNMIAG LPGSEESFTL EQFQHELDRY RGIDAEKLRT HLIYFLKEIT STADEAGVKL 250 260 270 280 290 300 VIHPDDPPCS ILGLPRIMSC AEDFQALIDA VPNESNGLCL CTGSLGVSCA NDLEGMMRRF 310 320 330 340 350 360 GDRINFVHFR STQRDAEGNF YEANHLEGDV DMYHVMKAFL ELQQRRKVSI PMRPDHGHQM 370 380 390 VDDLKKKTNP GYSCIGRLRG LAELRGLEMG IAKSIF

References

[1]

"Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J. Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25285 / NCTC 9343.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR626927 Genomic DNA. Translation: CAH05920.1.
RefSeq	YP_209882.1. NC_003228.3.
3D structure databases
ProteinModelPortal	Q5LIV6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5LIV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3286900.
GenomeReviews	Gene locus BF0142 in contig CR626927_GR.
KEGG	bfs:BF0142.
PATRIC	21036740. VBIBacFra29119_0136.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1312.
HOGENOM	HBG585927.
OMA	VHEEIKT.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	BFRA272559:BF0142-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_BACFN

Accession

Primary (citable) accession number: Q5LIV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	June 21, 2005
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program