Q5LIQ7 (AROK_BACFN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 40.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Shikimate kinase Short name=SK EC=2.7.1.71 | ||||
| Gene names |
| ||||
| Organism | Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 272559 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides |
Protein attributes
| Sequence length | 179 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP MF_00109 |
| Catalytic activity | ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109 |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00109 |
| Pathway | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109 |
| Subunit structure | Monomer By similarity. HAMAP MF_00109 |
| Subcellular location | Cytoplasm Probable HAMAP MF_00109. |
| Sequence similarities | Belongs to the shikimate kinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW shikimate kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 179 | 179 | Shikimate kinase HAMAP MF_00109 | PRO_0000237843 | |||||
Regions | |||||||||
| Nucleotide binding | 11 – 16 | 6 | ATP By similarity | ||||||
Sites | |||||||||
| Metal binding | 15 | 1 | Magnesium By similarity | ||||||
| Binding site | 33 | 1 | Substrate By similarity | ||||||
| Binding site | 57 | 1 | Substrate By similarity | ||||||
| Binding site | 79 | 1 | Substrate; via amide nitrogen By similarity | ||||||
| Binding site | 118 | 1 | ATP By similarity | ||||||
| Binding site | 140 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. Parkhill J.Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25285 / NCTC 9343. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR626927 Genomic DNA. Translation: CAH05969.1. |
| RefSeq | YP_209931.1. NC_003228.3. |
3D structure databases | |
| ProteinModelPortal | Q5LIQ7. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5LIQ7. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3288273. |
| GenomeReviews | Gene locus BF0192 in contig CR626927_GR. |
| KEGG | bfs:BF0192. |
| PATRIC | 21036846. VBIBacFra29119_0189. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0703. |
| HOGENOM | HBG335815. |
| OMA | NRRFMHD. |
| ProtClustDB | PRK13949. |
Enzyme and pathway databases | |
| BioCyc | BFRA272559:BF0192-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00109. Shikimate_kinase. [Tree] |
| InterPro | IPR000623. Shikimate_kinase. [Graphical view] |
| KO | K00891. |
| Pfam | PF01202. SKI. 1 hit. [Graphical view] |
| PRINTS | PR01100. SHIKIMTKNASE. |
| PROSITE | PS01128. SHIKIMATE_KINASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AROK_BACFN | ||||||||
| Accession | Primary (citable) accession number: Q5LIQ7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with