Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-fucose isomerase

Gene

fucI

Organism
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei337Proton acceptorUniRule annotation1
Metal bindingi337ManganeseUniRule annotation1
Active sitei361Proton acceptorUniRule annotation1
Metal bindingi361ManganeseUniRule annotation1
Metal bindingi528ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:BF0211
OrganismiBacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000006731 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000672131 – 590L-fucose isomeraseAdd BLAST590

Interactioni

Protein-protein interaction databases

STRINGi272559.BF0211

Structurei

3D structure databases

ProteinModelPortaliQ5LIN8
SMRiQ5LIN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2407 LUCA
HOGENOMiHOG000265624
KOiK01818
OMAiHAQKGLP

Family and domain databases

Gene3Di3.20.14.10, 1 hit
3.40.275.10, 1 hit
3.40.50.1070, 1 hit
HAMAPiMF_01254 Fucose_iso, 1 hit
InterProiView protein in InterPro
IPR004216 Fuc/Ara_isomerase_C
IPR038393 Fuc_iso_dom3_sf
IPR015888 Fuc_isomerase_C
IPR038391 Fucose_iso_dom1_sf
IPR012888 Fucose_iso_N1
IPR005763 Fucose_isomerase
IPR038392 Fucose_isomerase_dom2_sf
IPR009015 Fucose_isomerase_N/cen_sf
IPR012889 Fucose_isomerase_N2
PfamiView protein in Pfam
PF02952 Fucose_iso_C, 1 hit
PF07881 Fucose_iso_N1, 1 hit
PF07882 Fucose_iso_N2, 1 hit
SUPFAMiSSF50443 SSF50443, 1 hit
SSF53743 SSF53743, 1 hit
TIGRFAMsiTIGR01089 fucI, 1 hit

Sequencei

Sequence statusi: Complete.

Q5LIN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYPKIGIR PTIDGRQGGV RESLEEKTMN LAKAVAELIT SNLKNGDGTP
60 70 80 90 100
VECVIADGTI GRVAESAACA EKFEREGVGA TITVTSCWCY GAETMDMNPY
110 120 130 140 150
YPKAVWGFNG TERPGAVYLA AVLAGHAQKG LPAFGIYGRD VQDLNDNSIP
160 170 180 190 200
ADVAEKILRF ARAAQAVATM RGKSYLSMGS VSMGIAGSIV NPDFFQEYLG
210 220 230 240 250
MRNESIDLTE IIRRMAEGIY DKEEYAKAMA WTEKYCKKNE GNDFNIPEKT
260 270 280 290 300
KTRAQKDEDW EFIVKMTIIM RDLMQGNPKL KELGFKEEAL GHNAIAAGFQ
310 320 330 340 350
GQRQWTDFYP NGDFSEALLN TSFDWNGIRE AFVVTTENDA CNGVAMLFGH
360 370 380 390 400
LLTNRAQIFS DVRTYWSPEA VKRVTGKELT GMAANGIIHL INSGATTLDG
410 420 430 440 450
TGQQTNANGE PAMKPCWEIT EGEVEKCLEA TTWYPANRDY FRGGGFSSNF
460 470 480 490 500
LSKGGMPVTM MRLNLIKGLG PVLQIAEGWT VEIDPEIHKL LDERTDRTWP
510 520 530 540 550
TTWFVPRLCD KPAFKDVYSV MNNWGANHGA ISYGHIGQDV ITLASMLRIP
560 570 580 590
VCMHNVEEDQ IFRPAAWNAF GMDKEGADYR ACTTYGPIYK
Length:590
Mass (Da):65,371
Last modified:June 21, 2005 - v1
Checksum:i058D6B26DFD8DD08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA Translation: CAH05988.1
RefSeqiWP_010991938.1, NC_003228.3

Genome annotation databases

EnsemblBacteriaiCAH05988; CAH05988; BF9343_0209
KEGGibfs:BF9343_0209

Similar proteinsi

Entry informationi

Entry nameiFUCI_BACFN
AccessioniPrimary (citable) accession number: Q5LIN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 21, 2005
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health