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Q5LIN8

- FUCI_BACFN

UniProt

Q5LIN8 - FUCI_BACFN

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Protein

L-fucose isomerase

Gene

fucI

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Manganese.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei337 – 3371Proton acceptorUniRule annotation
Metal bindingi337 – 3371ManganeseUniRule annotation
Active sitei361 – 3611Proton acceptorUniRule annotation
Metal bindingi361 – 3611ManganeseUniRule annotation
Metal bindingi528 – 5281ManganeseUniRule annotation

GO - Molecular functioni

  1. L-fucose isomerase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-fucose catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-210-MONOMER.
UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:BF0211
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590L-fucose isomerasePRO_1000067213Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272559.BF0211.

Structurei

3D structure databases

ProteinModelPortaliQ5LIN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2407.
HOGENOMiHOG000265624.
KOiK01818.
OMAiFWEISDE.
OrthoDBiEOG6FJNCF.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5LIN8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKYPKIGIR PTIDGRQGGV RESLEEKTMN LAKAVAELIT SNLKNGDGTP
60 70 80 90 100
VECVIADGTI GRVAESAACA EKFEREGVGA TITVTSCWCY GAETMDMNPY
110 120 130 140 150
YPKAVWGFNG TERPGAVYLA AVLAGHAQKG LPAFGIYGRD VQDLNDNSIP
160 170 180 190 200
ADVAEKILRF ARAAQAVATM RGKSYLSMGS VSMGIAGSIV NPDFFQEYLG
210 220 230 240 250
MRNESIDLTE IIRRMAEGIY DKEEYAKAMA WTEKYCKKNE GNDFNIPEKT
260 270 280 290 300
KTRAQKDEDW EFIVKMTIIM RDLMQGNPKL KELGFKEEAL GHNAIAAGFQ
310 320 330 340 350
GQRQWTDFYP NGDFSEALLN TSFDWNGIRE AFVVTTENDA CNGVAMLFGH
360 370 380 390 400
LLTNRAQIFS DVRTYWSPEA VKRVTGKELT GMAANGIIHL INSGATTLDG
410 420 430 440 450
TGQQTNANGE PAMKPCWEIT EGEVEKCLEA TTWYPANRDY FRGGGFSSNF
460 470 480 490 500
LSKGGMPVTM MRLNLIKGLG PVLQIAEGWT VEIDPEIHKL LDERTDRTWP
510 520 530 540 550
TTWFVPRLCD KPAFKDVYSV MNNWGANHGA ISYGHIGQDV ITLASMLRIP
560 570 580 590
VCMHNVEEDQ IFRPAAWNAF GMDKEGADYR ACTTYGPIYK
Length:590
Mass (Da):65,371
Last modified:June 21, 2005 - v1
Checksum:i058D6B26DFD8DD08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH05988.1.
RefSeqiYP_209950.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH05988; CAH05988; BF9343_0209.
GeneIDi3286700.
KEGGibfs:BF0211.
PATRICi21036882. VBIBacFra29119_0207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH05988.1 .
RefSeqi YP_209950.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5LIN8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF0211.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH05988 ; CAH05988 ; BF9343_0209 .
GeneIDi 3286700.
KEGGi bfs:BF0211.
PATRICi 21036882. VBIBacFra29119_0207.

Phylogenomic databases

eggNOGi COG2407.
HOGENOMi HOG000265624.
KOi K01818.
OMAi FWEISDE.
OrthoDBi EOG6FJNCF.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00624 .
BioCyci BFRA272559:GKF0-210-MONOMER.

Family and domain databases

Gene3Di 3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPi MF_01254. Fucose_iso.
InterProi IPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view ]
Pfami PF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view ]
SUPFAMi SSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsi TIGR01089. fucI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiFUCI_BACFN
AccessioniPrimary (citable) accession number: Q5LIN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3