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Q5LI65 (GLSA_BACFN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutaminase
EC=3.5.1.2
Gene names
Name:glsA
Ordered Locus Names:BF0394
OrganismBacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]
Taxonomic identifier272559 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides ›

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the glutaminase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Glutaminase HAMAP-Rule MF_00313
PRO_1000048323

Sites

Binding site691Substrate By similarity
Binding site1201Substrate By similarity
Binding site1651Substrate By similarity
Binding site1721Substrate By similarity
Binding site1961Substrate By similarity
Binding site2481Substrate By similarity
Binding site2661Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5LI65 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: 56E079A059346DBF

FASTA32134,369
        10         20         30         40         50         60 
MDKKISISQI KEVVQQAYEQ VKGNTGGKNA DYIPYLANID KNLFGISVCL LNGQTITVGD 

        70         80         90        100        110        120 
FDYRFGIESV SKVHTAILIL RQYGAQKVLE MIGADATGLP FNSIIAILLE NDHPSTPLVN 

       130        140        150        160        170        180 
AGAISACSMV TPIGNSDKKW DAIVQNITDL CGSAPQLIEE LYKSETATNF NNRSIAWLLK 

       190        200        210        220        230        240 
NYNRIYDDPN MSLDLYTRQC SLGVTAQMLS VAAGTVANGG VNPVTKKQVF DAELTPKITS 

       250        260        270        280        290        300 
MIATVGFYEH SGDWMYTSGI PAKTGVGGGV MGVLPGVFGV SAFAPPLDGS GNSVKAQLAI 

       310        320 
KYIMNKLGLN VFNGARVTIV D

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References

[1]"Extensive DNA inversions in the B. fragilis genome control variable gene expression."
Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. expand/collapse author list , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J.
Science 307:1463-1465(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25285 / NCTC 9343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR626927 Genomic DNA. Translation: CAH06162.1.
RefSeqYP_210123.1. NC_003228.3.

3D structure databases

HSSPHSSP built from PDB template 1U60 based on UniProtKB P77454.
ProteinModelPortalQ5LI65.
ModBaseSearch...

Protein-protein interaction databases

STRING272559.BF0394.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH06162; CAH06162; BF9343_0383.
GeneID3286808.
KEGGbfs:BF0394.
PATRIC21037250. VBIBacFra29119_0389.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000022730.
KOK01425.
OMANRSIAWL.
ProtClustDBPRK12356.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. PBP_transp_fold. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA_BACFN
AccessionPrimary (citable) accession number: Q5LI65
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 21, 2005
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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