Q5LI41 (ACKA_BACFN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	BF0424

Organism

Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]

Taxonomic identifier

272559 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Acetate kinase HAMAP MF_00020		PRO_1000002209

Sequences

	Sequence		Length	Mass (Da)
	Q5LI41 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 6DE0C4B55787E457	FASTA	398	43,028
	10 20 30 40 50 60 MKVLVLNCGS SSIKYKLFDM DSKEVIAQGG IEKIGLKDSF LKLTLPNGEK KILEKDIPEH 70 80 90 100 110 120 TVGVEFILNT LVSPEYGAIQ SLEEINAVGH RMVHGGERFS KSVLLTKEVL EAFAACNDLA 130 140 150 160 170 180 PLHNPANLKG VDAITAILPN VPQIGVFDTA FHQTMPEHAY LYAIPYELYK KYGVRRYGFH 190 200 210 220 230 240 GTSHRYVSQR VCEYLGIKPE GLKLITCHIG NGGSIAAIKD GKCIDTSMGL TPLEGLMMGT 250 260 270 280 290 300 RSGDIDAGAV TFIMDKEGLT TTGISNLLNK KSGVAGMMNG SSDMRDLEAA VAKGDPQAIL 310 320 330 340 350 360 TEQMYFYRIK KYIGAYAAAL GGVDVILFTG GVGENQATCR AGVCEGLEFL GVKLDPEKNK 370 380 390 VRGEEAIIST DDSRVKVVVI PTDEELLIAS DTMAILDK

References

[1]

"Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J. Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25285 / NCTC 9343.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR626927 Genomic DNA. Translation: CAH06187.1.
RefSeq	YP_210147.1. NC_003228.3.
3D structure databases
HSSP	HSSP built from PDB template 1G99 based on UniProtKB P38502.
ProteinModelPortal	Q5LI41.
SMR	Q5LI41. Positions 1-398.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5LI41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3289091.
GenomeReviews	Gene locus BF0424 in contig CR626927_GR.
KEGG	bfs:BF0424.
PATRIC	21037308. VBIBacFra29119_0418.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	LIDMTNE.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	BFRA272559:BF0424-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_BACFN

Accession

Primary (citable) accession number: Q5LI41

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 21, 2005
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program