Reviewed, UniProtKB/Swiss-Prot Q5LHZ1 (ARGC_BACFN)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BF0480

Organism

Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]

Taxonomic identifier

272559 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000010977
Sites
	Active site	132	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5LHZ1-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: EC957B30A0ECB884	FASTA	322	35,907
	10 20 30 40 50 60 MIKAGIIGGA GYTAGELIRL LINHPETEIV FINSTSNAGN KITDVHEGLY GECDLAFTDE 70 80 90 100 110 120 LPLEDIDVLF FCTAHGDTKK FMESHNIPEE LKIIDLSMDY RIASPDHDFI YGLPELNRRA 130 140 150 160 170 180 TCTAKHVANP GCFATCIQLG LLPLAKHLML NEDVMVNAIT GSTGAGVKPG ATSHFSWRNN 190 200 210 220 230 240 NMSVYKAFEH QHVPEIKQSL KQLQNSFDAE IDFIPYRGDF PRGIFATLVV KTKVALEEIV 250 260 270 280 290 300 RMYEEYYAKD SFVHIVDKNI DLKQVVNTNK CLIHLEKHGD KLLIISCIDN LLKGASGQAV 310 320 HNMNLMFNLE ETVGLRLKPS AF

References

[1]

"Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J. Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR626927 Genomic DNA. Translation: CAH06239.1.
RefSeq	YP_210197.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3289109.
GenomeReviews	Gene locus BF0480 in contig CR626927_GR.
KEGG	bfs:BF0480.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5LHZ1.
OMA	Q5LHZ1. TSHFSWR.
Enzyme and pathway databases
BioCyc	BFRA272559:BF0480-MON.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BACFN

Accession

Primary (citable) accession number: Q5LHZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 21, 2005
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)