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Q5LHP5

- KITH_BACFN

UniProt

Q5LHP5 - KITH_BACFN

Protein

Thymidine kinase

Gene

tdk

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei96 – 961Proton acceptorUniRule annotation
    Metal bindingi152 – 1521ZincUniRule annotation
    Metal bindingi155 – 1551ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation
    Metal bindingi187 – 1871ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 308ATPUniRule annotation
    Nucleotide bindingi95 – 984ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciBFRA272559:GKF0-565-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:BF0583
    OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
    Taxonomic identifieri272559 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000006731: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Thymidine kinasePRO_0000174957Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272559.BF0583.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5LHP5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiYMAVCRE.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5LHP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLFSEDHIQ ETRRRGRIEV ICGSMFSGKT EELIRRMKRA KFARQRVEIF    50
    KPAIDTRYSE GDVVSHDSNS ISSTPIDSSA SILLFTSEID VVGIDEAQFF 100
    DSGLIDVCNQ LANNGVRVII AGLDMDFKGI PFGPMPALCA IADEVSKVHA 150
    ICVKCGQLAS FSHRTVKNDK QVLLGETAQY EPLCRECYQR ALQEDREKS 199
    Length:199
    Mass (Da):22,221
    Last modified:June 21, 2005 - v1
    Checksum:i210A59503FBB63FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR626927 Genomic DNA. Translation: CAH06335.1.
    RefSeqiWP_010992105.1. NC_003228.3.
    YP_210293.1. NC_003228.3.

    Genome annotation databases

    EnsemblBacteriaiCAH06335; CAH06335; BF9343_0556.
    GeneIDi3287448.
    KEGGibfs:BF0583.
    PATRICi21037628. VBIBacFra29119_0572.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR626927 Genomic DNA. Translation: CAH06335.1 .
    RefSeqi WP_010992105.1. NC_003228.3.
    YP_210293.1. NC_003228.3.

    3D structure databases

    ProteinModelPortali Q5LHP5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272559.BF0583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH06335 ; CAH06335 ; BF9343_0556 .
    GeneIDi 3287448.
    KEGGi bfs:BF0583.
    PATRICi 21037628. VBIBacFra29119_0572.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi YMAVCRE.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci BFRA272559:GKF0-565-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25285 / NCTC 9343.

    Entry informationi

    Entry nameiKITH_BACFN
    AccessioniPrimary (citable) accession number: Q5LHP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3