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Q5LHP5

- KITH_BACFN

UniProt

Q5LHP5 - KITH_BACFN

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Protein
Thymidine kinase
Gene
tdk, BF0583
Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Proton acceptor Reviewed prediction
Metal bindingi152 – 1521Zinc By similarity
Metal bindingi155 – 1551Zinc By similarity
Metal bindingi184 – 1841Zinc By similarity
Metal bindingi187 – 1871Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308ATP By similarity
Nucleotide bindingi95 – 984ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-565-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:BF0583
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Thymidine kinaseUniRule annotation
PRO_0000174957Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272559.BF0583.

Structurei

3D structure databases

ProteinModelPortaliQ5LHP5.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiYMAVCRE.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5LHP5-1 [UniParc]FASTAAdd to Basket

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MVLFSEDHIQ ETRRRGRIEV ICGSMFSGKT EELIRRMKRA KFARQRVEIF    50
KPAIDTRYSE GDVVSHDSNS ISSTPIDSSA SILLFTSEID VVGIDEAQFF 100
DSGLIDVCNQ LANNGVRVII AGLDMDFKGI PFGPMPALCA IADEVSKVHA 150
ICVKCGQLAS FSHRTVKNDK QVLLGETAQY EPLCRECYQR ALQEDREKS 199
Length:199
Mass (Da):22,221
Last modified:June 21, 2005 - v1
Checksum:i210A59503FBB63FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH06335.1.
RefSeqiWP_010992105.1. NC_003228.3.
YP_210293.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH06335; CAH06335; BF9343_0556.
GeneIDi3287448.
KEGGibfs:BF0583.
PATRICi21037628. VBIBacFra29119_0572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH06335.1 .
RefSeqi WP_010992105.1. NC_003228.3.
YP_210293.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5LHP5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272559.BF0583.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH06335 ; CAH06335 ; BF9343_0556 .
GeneIDi 3287448.
KEGGi bfs:BF0583.
PATRICi 21037628. VBIBacFra29119_0572.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi YMAVCRE.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci BFRA272559:GKF0-565-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiKITH_BACFN
AccessioniPrimary (citable) accession number: Q5LHP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 21, 2005
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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