Q5LHD6 (Q5LHD6_BACFN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative lipid-A-disaccharide synthase EMBL CAH06444.1
EC=2.4.1.182 EMBL CAH06444.1

Gene names

Ordered Locus Names:	BF0699
ORF Names:	BF9343_0665 EMBL CAH06444.1

Organism

Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP] EMBL CAH06444.1

Taxonomic identifier

272559 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL CAH06444.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5LHD6 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 2E859E437C28C3B4	FASTA	377	42,730
	10 20 30 40 50 60 MKYYLIVGEA SGDLHASHLM AALKEEDPEA EFRFFGGDLM AAVGGTMVKH YKELAYMGFI 70 80 90 100 110 120 PVLLHLTTIF ANMKRCKEDI VAWSPDVVIL VDYPGFNLDI AKFVHAKTKI PVYYYISPKI 130 140 150 160 170 180 WAWKEYRIKN IKRDVDELFS ILPFEVGFFK GHRYPIHYVG NPTVDEVTAF KASHQESFAD 190 200 210 220 230 240 FIADSELADK PIIALLAGSR KQEIKDNLPD MIRAASAFPG YQLVLAAAPG ISPEYYAKFV 250 260 270 280 290 300 KGTELAVIFD RTYRLLQQAD VALVTSGTAT LETALFRVPQ VVCYHTPVGK LVSFLRRHIL 310 320 330 340 350 360 KVKFISLVNL IAGREVVREL VADTMTVENM RAELERLLFR EDYRRKMLDG YEEMARLLGP 370 AGAPRHAARE MVKLLKK

References

[1]

"Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J. Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR626927 Genomic DNA. Translation: CAH06444.1.
RefSeq	YP_210402.1. NC_003228.3.
3D structure databases
ProteinModelPortal	Q5LHD6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5LHD6.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3288636.
GenomeReviews	Gene locus BF0699 in contig CR626927_GR.
KEGG	bfs:BF0699.
PATRIC	21037860. VBIBacFra29119_0687.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	PDFNLGL.
ProtClustDB	CLSK2391382.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5LHD6_BACFN

Accession

Primary (citable) accession number: Q5LHD6

Entry history

Integrated into UniProtKB/TrEMBL:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)