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Q5LH12

- PYRF_BACFN

UniProt

Q5LH12 - PYRF_BACFN

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei96 – 961Proton donorUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciBFRA272559:GKF0-804-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:BF0831
    OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
    Taxonomic identifieri272559 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000006731: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Orotidine 5'-phosphate decarboxylasePRO_1000138943Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272559.BF0831.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5LH12.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000250283.
    KOiK01591.
    OMAiDATHHLC.
    OrthoDBiEOG6DZF33.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5LH12-1 [UniParc]FASTAAdd to Basket

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    MNKQSLFENI KRKKSFLCVG LDTDIKKIPD HLLDDPDPIF AFNKAIVDAT    50
    ADYCIAYKPN LAFYESMGVK GWIAFEKTVN YIKENYPDQF IIADAKRGDI 100
    GNTSAMYART FFEELDIDSV TVAPYMGEDS VTPFLSYEGK WVILLALTSN 150
    KGSHDFQLTE DANGERLFEK VLKKSQEWAN DEQMMYVVGA TQGRAFEDIR 200
    KIVPNHFLLV PGIGAQGGSL EEVCKYGMNS TCGLIVNSSR GIIYVDKTEN 250
    FAAAARAAAK EVQEQMAEQL KAIL 274
    Length:274
    Mass (Da):30,634
    Last modified:June 21, 2005 - v1
    Checksum:i4C92B3DE82D61504
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR626927 Genomic DNA. Translation: CAH06574.1.
    RefSeqiYP_210526.1. NC_003228.3.

    Genome annotation databases

    EnsemblBacteriaiCAH06574; CAH06574; BF9343_0793.
    GeneIDi3288837.
    KEGGibfs:BF0831.
    PATRICi21038132. VBIBacFra29119_0822.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR626927 Genomic DNA. Translation: CAH06574.1 .
    RefSeqi YP_210526.1. NC_003228.3.

    3D structure databases

    ProteinModelPortali Q5LH12.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272559.BF0831.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH06574 ; CAH06574 ; BF9343_0793 .
    GeneIDi 3288837.
    KEGGi bfs:BF0831.
    PATRICi 21038132. VBIBacFra29119_0822.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000250283.
    KOi K01591.
    OMAi DATHHLC.
    OrthoDBi EOG6DZF33.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci BFRA272559:GKF0-804-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25285 / NCTC 9343.

    Entry informationi

    Entry nameiPYRF_BACFN
    AccessioniPrimary (citable) accession number: Q5LH12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3