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Q5LGW9

- G1092_BACFN

UniProt

Q5LGW9 - G1092_BACFN

Protein

Alpha-N-acetylgalactosaminidase

Gene

BF0874

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Glycosidase that has specific alpha-N-acetylgalactosaminidase activity.

    Catalytic activityi

    Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.1 Publication

    Cofactori

    Binds 1 NAD+ per subunit. The NAD cannot dissociate By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511NADBy similarity
    Binding sitei148 – 1481NADBy similarity
    Binding sitei177 – 1771SubstrateBy similarity
    Binding sitei211 – 2111NADBy similarity
    Binding sitei293 – 2931SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 302NADBy similarity
    Nucleotide bindingi99 – 1024NADBy similarity
    Nucleotide bindingi119 – 1202NADBy similarity
    Nucleotide bindingi194 – 1985NADBy similarity

    GO - Molecular functioni

    1. alpha-N-acetylgalactosaminidase activity Source: UniProtKB-EC
    2. oxidoreductase activity Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBFRA272559:GKF0-847-MONOMER.

    Protein family/group databases

    CAZyiGH109. Glycoside Hydrolase Family 109.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-N-acetylgalactosaminidase (EC:3.2.1.49)
    Alternative name(s):
    Glycosyl hydrolase family 109 protein
    Gene namesi
    Ordered Locus Names:BF0874
    OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
    Taxonomic identifieri272559 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000006731: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Alpha-N-acetylgalactosaminidasePRO_0000348547Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272559.BF0874.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5LGW9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni211 – 2144Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0673.
    HOGENOMiHOG000252553.
    OMAiYSIEHTG.
    OrthoDBiEOG61P6MK.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR000683. Oxidoreductase_N.
    [Graphical view]
    PfamiPF01408. GFO_IDH_MocA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5LGW9-1 [UniParc]FASTAAdd to Basket

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    MKTPSQTHVL GLAHPPLPMV RLAFIGLGNR GVLTLQRYLQ IEGVEIKALC    50
    EIREGNLVKA QKILREAGYP QPDGYTGPDG WKRMCERDDI DLVFICTDWL 100
    THTPMAVYSM EHGKHVAIEV PAAMTVEECW KLVDTAEKTR QHCMMLENCC 150
    YDPFALTTLN MAQQGVFGEI THVEGAYIHD LRSIYFADES KGGFHNHWGK 200
    KYSIEHTGNP YPTHGLGPVC QILNIHRGDR MNYLVSLSSL QAGMTEYARK 250
    NFGADSPEAR QKYLLGDMNT TLIQTVKGKS IMIQYNVVTP RPYSRLHTVC 300
    GTKGFAQKYP VPSIALEPDA GSPLEGKALE EIMERYKHPF TATFGTEAHR 350
    RNLPNEMNYV MDCRLIYCLR NGLPLDMDVY DAAEWSCITE LSEQSVLNGS 400
    IPVEIPDFTR GAWKKCHISR TSDLY 425
    Length:425
    Mass (Da):47,952
    Last modified:June 21, 2005 - v1
    Checksum:iFB747658272705FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM039447 Genomic DNA. Translation: CAJ01379.1.
    CR626927 Genomic DNA. Translation: CAH06617.1.
    RefSeqiWP_005813119.1. NC_003228.3.
    YP_210569.1. NC_003228.3.

    Genome annotation databases

    EnsemblBacteriaiCAH06617; CAH06617; BF9343_0836.
    GeneIDi3288533.
    KEGGibfs:BF0874.
    PATRICi21038216. VBIBacFra29119_0864.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM039447 Genomic DNA. Translation: CAJ01379.1 .
    CR626927 Genomic DNA. Translation: CAH06617.1 .
    RefSeqi WP_005813119.1. NC_003228.3.
    YP_210569.1. NC_003228.3.

    3D structure databases

    ProteinModelPortali Q5LGW9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272559.BF0874.

    Protein family/group databases

    CAZyi GH109. Glycoside Hydrolase Family 109.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH06617 ; CAH06617 ; BF9343_0836 .
    GeneIDi 3288533.
    KEGGi bfs:BF0874.
    PATRICi 21038216. VBIBacFra29119_0864.

    Phylogenomic databases

    eggNOGi COG0673.
    HOGENOMi HOG000252553.
    OMAi YSIEHTG.
    OrthoDBi EOG61P6MK.

    Enzyme and pathway databases

    BioCyci BFRA272559:GKF0-847-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR000683. Oxidoreductase_N.
    [Graphical view ]
    Pfami PF01408. GFO_IDH_MocA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ENZYME ACTIVITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25285 / NCTC 9343.

    Entry informationi

    Entry nameiG1092_BACFN
    AccessioniPrimary (citable) accession number: Q5LGW9
    Secondary accession number(s): A4Q8G0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3