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Q5LGW9

- G1092_BACFN

UniProt

Q5LGW9 - G1092_BACFN

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Protein

Alpha-N-acetylgalactosaminidase

Gene
BF0874
Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glycosidase that has specific alpha-N-acetylgalactosaminidase activity.

Catalytic activityi

Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.1 Publication

Cofactori

Binds 1 NAD+ per subunit. The NAD cannot dissociate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511NAD By similarity
Binding sitei148 – 1481NAD By similarity
Binding sitei177 – 1771Substrate By similarity
Binding sitei211 – 2111NAD By similarity
Binding sitei293 – 2931Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 302NAD By similarity
Nucleotide bindingi99 – 1024NAD By similarity
Nucleotide bindingi119 – 1202NAD By similarity
Nucleotide bindingi194 – 1985NAD By similarity

GO - Molecular functioni

  1. alpha-N-acetylgalactosaminidase activity Source: UniProtKB-EC
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-847-MONOMER.

Protein family/group databases

CAZyiGH109. Glycoside Hydrolase Family 109.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminidase (EC:3.2.1.49)
Alternative name(s):
Glycosyl hydrolase family 109 protein
Gene namesi
Ordered Locus Names:BF0874
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Alpha-N-acetylgalactosaminidasePRO_0000348547Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272559.BF0874.

Structurei

3D structure databases

ProteinModelPortaliQ5LGW9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni211 – 2144Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000252553.
OMAiYSIEHTG.
OrthoDBiEOG61P6MK.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LGW9-1 [UniParc]FASTAAdd to Basket

« Hide

MKTPSQTHVL GLAHPPLPMV RLAFIGLGNR GVLTLQRYLQ IEGVEIKALC    50
EIREGNLVKA QKILREAGYP QPDGYTGPDG WKRMCERDDI DLVFICTDWL 100
THTPMAVYSM EHGKHVAIEV PAAMTVEECW KLVDTAEKTR QHCMMLENCC 150
YDPFALTTLN MAQQGVFGEI THVEGAYIHD LRSIYFADES KGGFHNHWGK 200
KYSIEHTGNP YPTHGLGPVC QILNIHRGDR MNYLVSLSSL QAGMTEYARK 250
NFGADSPEAR QKYLLGDMNT TLIQTVKGKS IMIQYNVVTP RPYSRLHTVC 300
GTKGFAQKYP VPSIALEPDA GSPLEGKALE EIMERYKHPF TATFGTEAHR 350
RNLPNEMNYV MDCRLIYCLR NGLPLDMDVY DAAEWSCITE LSEQSVLNGS 400
IPVEIPDFTR GAWKKCHISR TSDLY 425
Length:425
Mass (Da):47,952
Last modified:June 21, 2005 - v1
Checksum:iFB747658272705FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039447 Genomic DNA. Translation: CAJ01379.1.
CR626927 Genomic DNA. Translation: CAH06617.1.
RefSeqiWP_005813119.1. NC_003228.3.
YP_210569.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH06617; CAH06617; BF9343_0836.
GeneIDi3288533.
KEGGibfs:BF0874.
PATRICi21038216. VBIBacFra29119_0864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039447 Genomic DNA. Translation: CAJ01379.1 .
CR626927 Genomic DNA. Translation: CAH06617.1 .
RefSeqi WP_005813119.1. NC_003228.3.
YP_210569.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5LGW9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF0874.

Protein family/group databases

CAZyi GH109. Glycoside Hydrolase Family 109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH06617 ; CAH06617 ; BF9343_0836 .
GeneIDi 3288533.
KEGGi bfs:BF0874.
PATRICi 21038216. VBIBacFra29119_0864.

Phylogenomic databases

eggNOGi COG0673.
HOGENOMi HOG000252553.
OMAi YSIEHTG.
OrthoDBi EOG61P6MK.

Enzyme and pathway databases

BioCyci BFRA272559:GKF0-847-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view ]
Pfami PF01408. GFO_IDH_MocA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ENZYME ACTIVITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiG1092_BACFN
AccessioniPrimary (citable) accession number: Q5LGW9
Secondary accession number(s): A4Q8G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 21, 2005
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi