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Q5LGW9

- G1092_BACFN

UniProt

Q5LGW9 - G1092_BACFN

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Protein

Alpha-N-acetylgalactosaminidase

Gene

BF0874

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Glycosidase that has specific alpha-N-acetylgalactosaminidase activity.

Catalytic activityi

Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.1 Publication

Cofactori

Binds 1 NAD+ per subunit. The NAD cannot dissociate (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511NADBy similarity
Binding sitei148 – 1481NADBy similarity
Binding sitei177 – 1771SubstrateBy similarity
Binding sitei211 – 2111NADBy similarity
Binding sitei293 – 2931SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 302NADBy similarity
Nucleotide bindingi99 – 1024NADBy similarity
Nucleotide bindingi119 – 1202NADBy similarity
Nucleotide bindingi194 – 1985NADBy similarity

GO - Molecular functioni

  1. alpha-N-acetylgalactosaminidase activity Source: UniProtKB-EC
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-847-MONOMER.

Protein family/group databases

CAZyiGH109. Glycoside Hydrolase Family 109.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminidase (EC:3.2.1.49)
Alternative name(s):
Glycosyl hydrolase family 109 protein
Gene namesi
Ordered Locus Names:BF0874
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Alpha-N-acetylgalactosaminidasePRO_0000348547Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272559.BF0874.

Structurei

3D structure databases

ProteinModelPortaliQ5LGW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni211 – 2144Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000252553.
OMAiYSIEHTG.
OrthoDBiEOG61P6MK.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LGW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTPSQTHVL GLAHPPLPMV RLAFIGLGNR GVLTLQRYLQ IEGVEIKALC
60 70 80 90 100
EIREGNLVKA QKILREAGYP QPDGYTGPDG WKRMCERDDI DLVFICTDWL
110 120 130 140 150
THTPMAVYSM EHGKHVAIEV PAAMTVEECW KLVDTAEKTR QHCMMLENCC
160 170 180 190 200
YDPFALTTLN MAQQGVFGEI THVEGAYIHD LRSIYFADES KGGFHNHWGK
210 220 230 240 250
KYSIEHTGNP YPTHGLGPVC QILNIHRGDR MNYLVSLSSL QAGMTEYARK
260 270 280 290 300
NFGADSPEAR QKYLLGDMNT TLIQTVKGKS IMIQYNVVTP RPYSRLHTVC
310 320 330 340 350
GTKGFAQKYP VPSIALEPDA GSPLEGKALE EIMERYKHPF TATFGTEAHR
360 370 380 390 400
RNLPNEMNYV MDCRLIYCLR NGLPLDMDVY DAAEWSCITE LSEQSVLNGS
410 420
IPVEIPDFTR GAWKKCHISR TSDLY
Length:425
Mass (Da):47,952
Last modified:June 21, 2005 - v1
Checksum:iFB747658272705FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039447 Genomic DNA. Translation: CAJ01379.1.
CR626927 Genomic DNA. Translation: CAH06617.1.
RefSeqiWP_005813119.1. NC_003228.3.
YP_210569.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH06617; CAH06617; BF9343_0836.
GeneIDi3288533.
KEGGibfs:BF0874.
PATRICi21038216. VBIBacFra29119_0864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM039447 Genomic DNA. Translation: CAJ01379.1 .
CR626927 Genomic DNA. Translation: CAH06617.1 .
RefSeqi WP_005813119.1. NC_003228.3.
YP_210569.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5LGW9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF0874.

Protein family/group databases

CAZyi GH109. Glycoside Hydrolase Family 109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH06617 ; CAH06617 ; BF9343_0836 .
GeneIDi 3288533.
KEGGi bfs:BF0874.
PATRICi 21038216. VBIBacFra29119_0864.

Phylogenomic databases

eggNOGi COG0673.
HOGENOMi HOG000252553.
OMAi YSIEHTG.
OrthoDBi EOG61P6MK.

Enzyme and pathway databases

BioCyci BFRA272559:GKF0-847-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view ]
Pfami PF01408. GFO_IDH_MocA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ENZYME ACTIVITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiG1092_BACFN
AccessioniPrimary (citable) accession number: Q5LGW9
Secondary accession number(s): A4Q8G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 21, 2005
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3