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Protein

Alpha-galactosidase

Gene

BF9343_1347

Organism
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationImported, Hydrolase

Protein family/group databases

CAZyiGH27 Glycoside Hydrolase Family 27

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-galactosidaseUniRule annotation (EC:3.2.1.22UniRule annotation)
Alternative name(s):
MelibiaseUniRule annotation
Gene namesi
ORF Names:BF9343_1347Imported
OrganismiBacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)Imported
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000006731 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500425902125 – 500Alpha-galactosidaseSequence analysisAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi215 ↔ 245Combined sources

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi272559.BF1418

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NZJX-ray1.57A24-500[»]
ProteinModelPortaliQ5LFG6
SMRiQ5LFG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 64He_PIG_assocInterPro annotationAdd BLAST29

Sequence similaritiesi

Belongs to the glycosyl hydrolase 27 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4105EX0 Bacteria
ENOG410XPF1 LUCA
HOGENOMiHOG000161224
KOiK07407
OMAiDDLWDRW

Family and domain databases

CDDicd14792 GH27, 1 hit
Gene3Di2.60.40.101 hit
2.60.40.11801 hit
3.20.20.701 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR019599 Alpha-galactosidase_NEW1
IPR015919 Cadherin-like
IPR002241 Glyco_hydro_27
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR008009 He_PIG
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF05345 He_PIG, 1 hit
PF10632 He_PIG_assoc, 1 hit
PF16499 Melibiase_2, 1 hit
PRINTSiPR00740 GLHYDRLASE27
SUPFAMiSSF49313 SSF49313, 1 hit
SSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Q5LFG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPYFIAFL LFLALWTAIP SVFAGDVVLK VFEGKPRINS PHIIGNYPST
60 70 80 90 100
PFIFYIPTSG QRPMQWSAEK LPEGLELDSK TGIISGVMTS KGDYTVTLKA
110 120 130 140 150
ENALGVSVKQ LVIRIGDELL LTPPMGWNSW NTFGQHLTEE LVLQTADAMI
160 170 180 190 200
TNGMRDLGYS YINIDDFWQL PERGADGHLQ IDKTKFPRGI KYVADYLHER
210 220 230 240 250
GFKLGIYSDA AEKTCGGVCG SYGYEETDAK DFASWGVDLL KYDYCNAPVD
260 270 280 290 300
RVEAMERYAK MGRALRATNR SIVYSVCEWG QREPWKWAKQ VGGHLWRVSG
310 320 330 340 350
DIGDIWYRDG NRVGGLHGIL NILEINAPLS EYAGPSGWND PDMLVVGIDG
360 370 380 390 400
KSMSIGYESE GCTQEQYKSH FSLWCMMASP LLSGNDVRNM NDSTLKILLD
410 420 430 440 450
PDLIAINQDV LGRQAERSIR SDHYDIWVKP LADGRKAVAC FNRASSPQTV
460 470 480 490 500
ILNENTIADL SFEQIYCLDN HLTKSGSDSK ELIVKLAPYQ CKVYIFGKTD
Length:500
Mass (Da):55,960
Last modified:June 21, 2005 - v1
Checksum:iCC98E09EE123EB47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA Translation: CAH07128.1
RefSeqiWP_010992469.1, NC_003228.3

Genome annotation databases

EnsemblBacteriaiCAH07128; CAH07128; BF9343_1347
KEGGibfs:BF9343_1347

Similar proteinsi

Entry informationi

Entry nameiQ5LFG6_BACFN
AccessioniPrimary (citable) accession number: Q5LFG6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 21, 2005
Last sequence update: June 21, 2005
Last modified: February 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported