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Q5LDN2 (GCSP_BACFN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:BF2079
OrganismBacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]
Taxonomic identifier272559 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length949 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 949949Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227092

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5LDN2 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: DFCC4995CFFE151D

FASTA949104,591
        10         20         30         40         50         60 
MKTDLLACRH IGVNKADAEV MLRKIGVASL DELIDKTIPA NIRLKAPLAL PAPMTEYEFA 

        70         80         90        100        110        120 
RHIAELAGKN KLFTTYIGMG WYNTITPAVI QRNVFENPVW YTSYTPYQTE VSQGRLEALM 

       130        140        150        160        170        180 
NFQTAVCDLT AMPLANCSLL DEATAAAEAV TMMYGLRSRN QQKAGANVVF IDENIFPQTL 

       190        200        210        220        230        240 
AVITTRAIPQ GIEIRTGKFR DLEFTDDLFA CVLQYPNANG NAEDYREFTE KAHTANCKVA 

       250        260        270        280        290        300 
VAADILSLAL LTPPGEWGAD IVFGTTQRLG TPMFYGGPSA GYFATRDEYK RNMPGRIIGW 

       310        320        330        340        350        360 
SKDKYGKLCY RMALQTREQH IKREKATSNI CTAQALLATM AGFYTVYHGQ EGIRNIASRI 

       370        380        390        400        410        420 
HSITVFLEKS IGKLGFKQVN KQYFDTLRFI LPDSVSAQQI RTIALSKEVN LRYFDNGDVG 

       430        440        450        460        470        480 
LSIDETTDVA AANILLSIFA IAAGKDFQKV DDIPEATIIS EELKRQTPYL THEVFSKYHT 

       490        500        510        520        530        540 
ETEMMRYIKR LDRKDISLAQ SMISLGSCTM KLNAAAEMLP LSCAEFMCMH PLVPEDQAAG 

       550        560        570        580        590        600 
YRELIHNLSE ELKVITGFAG VSLQPNSGAA GEYAGLRTIR AYLESIGQGH RNKVLIPASA 

       610        620        630        640        650        660 
HGTNPASAIQ AGFTTVTCAC DEHGNVDMDD LRAKAEENKD DLAALMITYP STHGIFETEI 

       670        680        690        700        710        720 
VEICQIIHAC GAQVYMDGAN MNAQVGLTNP GFIGADVCHL NLHKTFASPH GGGGPGVGPI 

       730        740        750        760        770        780 
CVAEHLVPFL PGHGLFGNSQ NEVSAAPFGS AGILPITYGY IRMMGAEGLT MATKTAILNA 

       790        800        810        820        830        840 
NYLAACLKDT YGIVYRGANG FVGHEMILEC RKVYEETGIS ENDIAKRLMD YGYHAPTLSF 

       850        860        870        880        890        900 
PVHGTLMIEP TESESLSELD NFVLTMLTIW NEIQEVKNGE ADKEDNVLIN APHPEYEVVS 

       910        920        930        940 
DQWEHCYTRE KAAYPIESVR ENKFWVNVAR VDNTLGDRKL LPTCYGCFD 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR626927 Genomic DNA. Translation: CAH07776.1.
RefSeqYP_211707.1. NC_003228.3.

3D structure databases

ProteinModelPortalQ5LDN2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272559.BF2079.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH07776; CAH07776; BF9343_1995.
GeneID3285560.
KEGGbfs:BF2079.
PATRIC21040630. VBIBacFra29119_2059.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAHRYRTET.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycBFRA272559:GKF0-2014-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_BACFN
AccessionPrimary (citable) accession number: Q5LDN2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 21, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families