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Q5LDN2

- GCSP_BACFN

UniProt

Q5LDN2 - GCSP_BACFN

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, BF2079
Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-2014-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:BF2079
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000227092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi272559.BF2079.

Structurei

3D structure databases

ProteinModelPortaliQ5LDN2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHRYRTET.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5LDN2-1 [UniParc]FASTAAdd to Basket

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MKTDLLACRH IGVNKADAEV MLRKIGVASL DELIDKTIPA NIRLKAPLAL    50
PAPMTEYEFA RHIAELAGKN KLFTTYIGMG WYNTITPAVI QRNVFENPVW 100
YTSYTPYQTE VSQGRLEALM NFQTAVCDLT AMPLANCSLL DEATAAAEAV 150
TMMYGLRSRN QQKAGANVVF IDENIFPQTL AVITTRAIPQ GIEIRTGKFR 200
DLEFTDDLFA CVLQYPNANG NAEDYREFTE KAHTANCKVA VAADILSLAL 250
LTPPGEWGAD IVFGTTQRLG TPMFYGGPSA GYFATRDEYK RNMPGRIIGW 300
SKDKYGKLCY RMALQTREQH IKREKATSNI CTAQALLATM AGFYTVYHGQ 350
EGIRNIASRI HSITVFLEKS IGKLGFKQVN KQYFDTLRFI LPDSVSAQQI 400
RTIALSKEVN LRYFDNGDVG LSIDETTDVA AANILLSIFA IAAGKDFQKV 450
DDIPEATIIS EELKRQTPYL THEVFSKYHT ETEMMRYIKR LDRKDISLAQ 500
SMISLGSCTM KLNAAAEMLP LSCAEFMCMH PLVPEDQAAG YRELIHNLSE 550
ELKVITGFAG VSLQPNSGAA GEYAGLRTIR AYLESIGQGH RNKVLIPASA 600
HGTNPASAIQ AGFTTVTCAC DEHGNVDMDD LRAKAEENKD DLAALMITYP 650
STHGIFETEI VEICQIIHAC GAQVYMDGAN MNAQVGLTNP GFIGADVCHL 700
NLHKTFASPH GGGGPGVGPI CVAEHLVPFL PGHGLFGNSQ NEVSAAPFGS 750
AGILPITYGY IRMMGAEGLT MATKTAILNA NYLAACLKDT YGIVYRGANG 800
FVGHEMILEC RKVYEETGIS ENDIAKRLMD YGYHAPTLSF PVHGTLMIEP 850
TESESLSELD NFVLTMLTIW NEIQEVKNGE ADKEDNVLIN APHPEYEVVS 900
DQWEHCYTRE KAAYPIESVR ENKFWVNVAR VDNTLGDRKL LPTCYGCFD 949
Length:949
Mass (Da):104,591
Last modified:June 21, 2005 - v1
Checksum:iDFCC4995CFFE151D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH07776.1.
RefSeqiYP_211707.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH07776; CAH07776; BF9343_1995.
GeneIDi3285560.
KEGGibfs:BF2079.
PATRICi21040630. VBIBacFra29119_2059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH07776.1 .
RefSeqi YP_211707.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5LDN2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF2079.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH07776 ; CAH07776 ; BF9343_1995 .
GeneIDi 3285560.
KEGGi bfs:BF2079.
PATRICi 21040630. VBIBacFra29119_2059.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi HRYRTET.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BFRA272559:GKF0-2014-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiGCSP_BACFN
AccessioniPrimary (citable) accession number: Q5LDN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 21, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi