Q5LD98 (Q5LD98_BACFN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative dihydroorotate dehydrogenase, catalytic subunit EMBL CAH07912.1
EC=1.3.3.1 EMBL CAH07912.1

Gene names

Name:	pyrD2 EMBL CAH07912.1
Ordered Locus Names:	BF2218
ORF Names:	BF9343_2131 EMBL CAH07912.1

Organism

Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP] EMBL CAH07912.1

Taxonomic identifier

272559 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity. SAAS SAAS012135
Catalytic activity	(S)-dihydroorotate + a quinone = orotate + a quinol. SAAS SAAS012135
Cofactor	Binds 1 FMN per subunit By similarity. SAAS SAAS012135
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. SAAS SAAS012135
Subunit structure	Monomer By similarity. SAAS SAAS012135

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis SAAS SAAS012135
Cellular component	Membrane SAAS SAAS012135
Ligand	FMN SAAS SAAS012135 Flavoprotein SAAS SAAS012135
Molecular function	Oxidoreductase SAAS SAAS012135 EMBL CAH07912.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	dihydroorotate oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	178	1	Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

	Sequence		Length	Mass (Da)
	Q5LD98 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: D276C007BE48A85E	FASTA	331	36,910
	10 20 30 40 50 60 MYKQTIRPVL FLMEPEKVHA LLVSCLKCYR HLPWCRCWIR HLYTCSDKQL IWNHLTFRNR 70 80 90 100 110 120 IGLSAGFDKG AEIFDELADC GFGFIEVGTV TPDSQDGNPR PRIFRLPQCE SLISRTGFNN 130 140 150 160 170 180 PGLDVIKRRL EQKSGSYVLG VNINKNPSSE GEQAVADFLR LYKELHPHVG YFTLNWGSVD 190 200 210 220 230 240 VALMKQVLQG LAVFRVEQNI HVPLLLKLPA DITEEGMDDV IDCTRLYRVD GVIATGPTME 250 260 270 280 290 300 RSYLKGYSPA QLQKIGSGGI SGRGIGERSL KAVSYLRAHA GKSLLIVGAG GIITPADARR 310 320 330 MLDAGANLIQ IYSSFIYEGP GIVKKMIQEI K

References

[1]

"Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J. Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR626927 Genomic DNA. Translation: CAH07912.1.
RefSeq	YP_211841.1. NC_003228.3.
3D structure databases
ProteinModelPortal	Q5LD98.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5LD98.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3289318.
GenomeReviews	Gene locus BF2218 in contig CR626927_GR.
KEGG	bfs:BF2218.
PATRIC	21040926. VBIBacFra29119_2206.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0167.
HOGENOM	HBG351027.
OMA	SYVTVNI.
ProtClustDB	PRK05286.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR012135. Dihydroorotate_DH_1_2. IPR005719. Dihydroorotate_DH_2. IPR001295. Dihydroorotate_DH_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00226.
Pfam	PF01180. DHO_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMs	TIGR01036. PyrD_sub2. 1 hit.
PROSITE	PS00911. DHODEHASE_1. 1 hit. PS00912. DHODEHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5LD98_BACFN

Accession

Primary (citable) accession number: Q5LD98

Entry history

Integrated into UniProtKB/TrEMBL:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)