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Q5LD60

- FTHS_BACFN

UniProt

Q5LD60 - FTHS_BACFN

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-2189-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BF2256
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000199334Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272559.BF2256.

Structurei

3D structure databases

ProteinModelPortaliQ5LD60.
SMRiQ5LD60. Positions 4-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000239685.
KOiK01938.
OMAiIPRESGF.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LD60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIEIARS VELKKIKQVA ESIGIPRDEV ENYGRYIAKI PEYLIDEEKV
60 70 80 90 100
KKSNLILVTA ITATKAGIGK TTVSIGLALG LNKIGKKAIV ALREPSLGPC
110 120 130 140 150
FGMKGGAAGG GYAQVLPMEK INLHFTGDFH AITSAHNMIS ALLDNYLYQN
160 170 180 190 200
QSKGFGLKEI LWRRVLDVND RSLRNIVVGL GPKTNGITQE SGFDITPASE
210 220 230 240 250
IMAILCLSKD VDDLRRRIEN ILLGYTYDNK PFTVKDLGVA GAITVLLKDA
260 270 280 290 300
IHPNLVQTTE GTAAFVHGGP FANIAHGCNS ILATKMAMTF GDYVITEAGF
310 320 330 340 350
GADLGAEKFY NIKCRKSGLQ PRLTVIVATA QGLKMHGGVS LDRIKEPNLE
360 370 380 390 400
GLREGLRNLD KHVRNLHSFG QTVIVAFNKF ASDTDEEMEL LREHCEQLGV
410 420 430 440 450
GYAINNAFSE GGEGAVDLAN LVVETIENKP SEPLQFTYND EDSVQQKIEK
460 470 480 490 500
VATNLYGASV VTYSTLTRNK IKLIEEMGIG HYPVCIAKTQ YSFSADPKVY
510 520 530 540 550
GAVDNFELHI KDIVINNGAE MIVAIAGEIM RMPGLPKEPQ ALHIDIVDGN

IEGLS
Length:555
Mass (Da):60,418
Last modified:June 21, 2005 - v1
Checksum:iE5497181B20F7530
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA. Translation: CAH07950.1.
RefSeqiYP_211879.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH07950; CAH07950; BF9343_2169.
GeneIDi3285334.
KEGGibfs:BF2256.
PATRICi21041010. VBIBacFra29119_2248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA. Translation: CAH07950.1 .
RefSeqi YP_211879.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5LD60.
SMRi Q5LD60. Positions 4-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF2256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH07950 ; CAH07950 ; BF9343_2169 .
GeneIDi 3285334.
KEGGi bfs:BF2256.
PATRICi 21041010. VBIBacFra29119_2248.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000239685.
KOi K01938.
OMAi IPRESGF.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BFRA272559:GKF0-2189-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiFTHS_BACFN
AccessioniPrimary (citable) accession number: Q5LD60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 21, 2005
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3