Q5LCV9 (XYLA_BACFN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylose isomerase
EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	BF2356

Organism

Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]

Taxonomic identifier

272559 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455
Subunit structure	Homotetramer By similarity. HAMAP MF_00455
Subcellular location	Cytoplasm By similarity HAMAP MF_00455.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW xylose isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Xylose isomerase HAMAP MF_00455		PRO_0000236957
Sites
	Active site	103	1	By similarity
	Active site	106	1	By similarity
	Metal binding	234	1	Magnesium 1 By similarity
	Metal binding	270	1	Magnesium 1 By similarity
	Metal binding	270	1	Magnesium 2 By similarity
	Metal binding	273	1	Magnesium 2 By similarity
	Metal binding	298	1	Magnesium 1 By similarity
	Metal binding	309	1	Magnesium 2 By similarity
	Metal binding	311	1	Magnesium 2 By similarity
	Metal binding	341	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5LCV9 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 2E86A483ED326403	FASTA	439	49,014
	10 20 30 40 50 60 MATKEYFPGI GKIKFEGKDS KNPMAFRYYD AEKMINGRSM KDWLKFAMAW WHTLCAEGGD 70 80 90 100 110 120 QFGGGTKQFP WNGDPDPVQA AKNKMDAGFE FMQKMGIGYY CFHDVDLVTE ADSIEAYEAN 130 140 150 160 170 180 LKELVAYAKQ KQAETGIKLL WGTANVFSHA RYMNGAATNP DFDVVARAAV QIKNAIDATI 190 200 210 220 230 240 ELGGTNYVFW GGREGYMSLL NTDQKREKEH LAQMLTIARD YGRARGFKGT FLIEPKPMEP 250 260 270 280 290 300 TKHQYDVDTE TVIGFLKAHG LNQDFKVNIE VNHATLAGHT FEHELAVAVD NGMLGSIDAN 310 320 330 340 350 360 RGDYQNGWDT DQFPIDNFEL TQAMMQIIRN DGLGNGGTNF DAKTRRNSTD PEDIFIAHIA 370 380 390 400 410 420 GMDAMARALE SAANLLNESP YQKMLSDRYA SFDAGKGKEF EEGKLSLEEL VAYAKANGEP 430 KQTSGQQELY EALVNIYSL

References

[1]

"Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J. Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25285 / NCTC 9343.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR626927 Genomic DNA. Translation: CAH08054.1.
RefSeq	YP_211980.1. NC_003228.3.
3D structure databases
ProteinModelPortal	Q5LCV9.
SMR	Q5LCV9. Positions 4-439.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5LCV9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3285220.
GenomeReviews	Gene locus BF2356 in contig CR626927_GR.
KEGG	bfs:BF2356.
PATRIC	21041234. VBIBacFra29119_2358.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2115.
HOGENOM	HBG297199.
OMA	LLGWDTD.
ProtClustDB	PRK05474.
Enzyme and pathway databases
BioCyc	BFRA272559:BF2356-MONOMER.
Family and domain databases
HAMAP	MF_00455. Xylose_isom_A. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01805.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR02630. Xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_BACFN

Accession

Primary (citable) accession number: Q5LCV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	June 21, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program