Q5LCF3 (GCP_BACFN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp

Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein

Gene names

Name:	gcp
Ordered Locus Names:	BF2512

Organism

Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]

Taxonomic identifier

272559 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine By similarity. HAMAP MF_01445
Subcellular location	Cytoplasm Potential HAMAP MF_01445.
Sequence similarities	Belongs to the KAE1 / YgjD family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp HAMAP MF_01445		PRO_0000303272

Sequences

	Sequence		Length	Mass (Da)
	Q5LCF3 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: F7521CDA5B140350	FASTA	339	36,956
	10 20 30 40 50 60 MSTIILGIES SCDDTSAAVI KDGYLLSNVV SSQAVHEAYG GVVPELASRA HQQNIVPVVH 70 80 90 100 110 120 EALKRAGVTK EELSAVAFTR GPGLMGSLLV GVSFAKGFAR SLNIPMIDVN HLTGHVLAHF 130 140 150 160 170 180 IKEEGEANEQ PDFPFLCLLV SGGNSQIILV KAYNDMEILG QTIDDAAGEA IDKCSKVMGL 190 200 210 220 230 240 GYPGGPIIDR LARQGNPKAY TFSKPHISGL DYSFSGLKTS FLYSLRDWMK EDPDFIEHHK 250 260 270 280 290 300 NDLAASLEAT VVDILMDKLR KAAKQYKINE VAVAGGVSAN NGLRNAFREH AEKYGWKIFI 310 320 330 PKFSYTTDNA AMIAITGYFK YQDKDFCSIE QPAYSRVTL

References

[1]

"Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J. Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25285 / NCTC 9343.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR626927 Genomic DNA. Translation: CAH08212.1.
RefSeq	YP_212136.1. NC_003228.3.
3D structure databases
ProteinModelPortal	Q5LCF3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5LCF3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3287475.
GenomeReviews	Gene locus BF2512 in contig CR626927_GR.
KEGG	bfs:BF2512.
PATRIC	21041570. VBIBacFra29119_2519.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0533.
HOGENOM	HBG304663.
OMA	MEVIGQT.
ProtClustDB	PRK09604.
Enzyme and pathway databases
BioCyc	BFRA272559:BF2512-MONOMER.
Family and domain databases
HAMAP	MF_01445. gcp. [Tree]
InterPro	IPR022450. Pept_M22_O-sialoglycopept. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
KO	K01409.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR03723. Bact_gcp. 1 hit. TIGR00329. Gcp_kae1. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BACFN

Accession

Primary (citable) accession number: Q5LCF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 21, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program