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Q5LAZ8

- HISX_BACFN

UniProt

Q5LAZ8 - HISX_BACFN

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Protein

Histidinol dehydrogenase

Gene
hisD, BF3029
Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241NAD By similarity
Binding sitei186 – 1861NAD By similarity
Binding sitei209 – 2091NAD By similarity
Binding sitei233 – 2331Substrate By similarity
Metal bindingi255 – 2551Zinc By similarity
Binding sitei255 – 2551Substrate By similarity
Metal bindingi258 – 2581Zinc By similarity
Binding sitei258 – 2581Substrate By similarity
Active sitei322 – 3221Proton acceptor By similarity
Active sitei323 – 3231Proton acceptor By similarity
Binding sitei323 – 3231Substrate By similarity
Metal bindingi356 – 3561Zinc By similarity
Binding sitei356 – 3561Substrate By similarity
Binding sitei410 – 4101Substrate By similarity
Metal bindingi415 – 4151Zinc By similarity
Binding sitei415 – 4151Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-2985-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BF3029
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histidinol dehydrogenaseUniRule annotationPRO_0000135731Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272559.BF3029.

Structurei

3D structure databases

ProteinModelPortaliQ5LAZ8.
SMRiQ5LAZ8. Positions 8-428.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiWALMIER.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LAZ8-1 [UniParc]FASTAAdd to Basket

« Hide

MKLIKYPDRS QWNEILKRPV LETENLFDTV RNIINRVRAG GDRVVMEYEA    50
VFDKAELTSL AVTSAEIEEA EKEVPIELKA AIYLAKRNIE TFHSAQRFEG 100
KKVDTMEGVT CWQKAVAIEK VGLYIPGGTA PLFSTVLMLA IPAKIAGCKE 150
IVLCTPPDKN GKVHPAILFA ARLAGVSKIF KAGGVQAIAA MAYGTESIPK 200
VYKIFGPGNQ YVTAAKQLVS LRDVAIDMPA GPSEVEVLAD ESANPVFVAA 250
DLLSQAEHGV DSQAMLVTTS EKLQTEVVYE VERQLGYLTR RDIAEKSLAS 300
SKLILVKDME EALELTNAYA PEHLIIETKD YMEVAGQIVN AGSVFLGAFS 350
PESAGDYASG TNHTLPTNGY AKAYSGVSLD SFIRKITFQE ILPSGMSAIG 400
PAIEVMAANE HLDAHKNAVT VRLEEIRK 428
Length:428
Mass (Da):46,535
Last modified:June 21, 2005 - v1
Checksum:i731DC2A51FA3930E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH08724.1.
RefSeqiYP_212643.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH08724; CAH08724; BF9343_2943.
GeneIDi3289178.
KEGGibfs:BF3029.
PATRICi21042676. VBIBacFra29119_3058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH08724.1 .
RefSeqi YP_212643.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5LAZ8.
SMRi Q5LAZ8. Positions 8-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF3029.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH08724 ; CAH08724 ; BF9343_2943 .
GeneIDi 3289178.
KEGGi bfs:BF3029.
PATRICi 21042676. VBIBacFra29119_3058.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi WALMIER.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BFRA272559:GKF0-2985-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiHISX_BACFN
AccessioniPrimary (citable) accession number: Q5LAZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 21, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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