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Q5LAZ8

- HISX_BACFN

UniProt

Q5LAZ8 - HISX_BACFN

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241NADUniRule annotation
Binding sitei186 – 1861NADUniRule annotation
Binding sitei209 – 2091NADUniRule annotation
Binding sitei233 – 2331SubstrateUniRule annotation
Metal bindingi255 – 2551ZincUniRule annotation
Binding sitei255 – 2551SubstrateUniRule annotation
Metal bindingi258 – 2581ZincUniRule annotation
Binding sitei258 – 2581SubstrateUniRule annotation
Active sitei322 – 3221Proton acceptorUniRule annotation
Active sitei323 – 3231Proton acceptorUniRule annotation
Binding sitei323 – 3231SubstrateUniRule annotation
Metal bindingi356 – 3561ZincUniRule annotation
Binding sitei356 – 3561SubstrateUniRule annotation
Binding sitei410 – 4101SubstrateUniRule annotation
Metal bindingi415 – 4151ZincUniRule annotation
Binding sitei415 – 4151SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-2985-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:BF3029
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histidinol dehydrogenasePRO_0000135731Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272559.BF3029.

Structurei

3D structure databases

ProteinModelPortaliQ5LAZ8.
SMRiQ5LAZ8. Positions 8-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiWALMIER.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5LAZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLIKYPDRS QWNEILKRPV LETENLFDTV RNIINRVRAG GDRVVMEYEA
60 70 80 90 100
VFDKAELTSL AVTSAEIEEA EKEVPIELKA AIYLAKRNIE TFHSAQRFEG
110 120 130 140 150
KKVDTMEGVT CWQKAVAIEK VGLYIPGGTA PLFSTVLMLA IPAKIAGCKE
160 170 180 190 200
IVLCTPPDKN GKVHPAILFA ARLAGVSKIF KAGGVQAIAA MAYGTESIPK
210 220 230 240 250
VYKIFGPGNQ YVTAAKQLVS LRDVAIDMPA GPSEVEVLAD ESANPVFVAA
260 270 280 290 300
DLLSQAEHGV DSQAMLVTTS EKLQTEVVYE VERQLGYLTR RDIAEKSLAS
310 320 330 340 350
SKLILVKDME EALELTNAYA PEHLIIETKD YMEVAGQIVN AGSVFLGAFS
360 370 380 390 400
PESAGDYASG TNHTLPTNGY AKAYSGVSLD SFIRKITFQE ILPSGMSAIG
410 420
PAIEVMAANE HLDAHKNAVT VRLEEIRK
Length:428
Mass (Da):46,535
Last modified:June 21, 2005 - v1
Checksum:i731DC2A51FA3930E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH08724.1.
RefSeqiWP_010993237.1. NC_003228.3.
YP_212643.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH08724; CAH08724; BF9343_2943.
GeneIDi3289178.
KEGGibfs:BF3029.
PATRICi21042676. VBIBacFra29119_3058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH08724.1 .
RefSeqi WP_010993237.1. NC_003228.3.
YP_212643.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5LAZ8.
SMRi Q5LAZ8. Positions 8-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF3029.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH08724 ; CAH08724 ; BF9343_2943 .
GeneIDi 3289178.
KEGGi bfs:BF3029.
PATRICi 21042676. VBIBacFra29119_3058.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi WALMIER.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BFRA272559:GKF0-2985-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiHISX_BACFN
AccessioniPrimary (citable) accession number: Q5LAZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3