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Q5LA67 (UNG1_BACFN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uracil-DNA glycosylase 1
Short name=UDG 1
EC=3.2.2.27
Gene names
Name:ung1
Ordered Locus Names:BF3312
OrganismBacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]
Taxonomic identifier272559 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides ›

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity. HAMAP-Rule MF_00148

Catalytic activity

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil. HAMAP-Rule MF_00148

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00148.

Sequence similarities

Belongs to the uracil-DNA glycosylase family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processbase-excision repair

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuracil DNA N-glycosylase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Uracil-DNA glycosylase 1 HAMAP-Rule MF_00148
PRO_0000176059

Sites

Active site651Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5LA67 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: 4941421E5BFF2050

FASTA22025,126
        10         20         30         40         50         60 
MNVKIESSWQ QRLQEEFDKP YFEKLVNFVK NEYGKAHILP PGHQIFHVFN SCPFQNVKVV 

        70         80         90        100        110        120 
ILGQDPYPNP GQYYGICFSV PDGVAIPGSL SNIFKEIHQD LGKPLPNSGN LDRWVKQGVF 

       130        140        150        160        170        180 
PMNSVLTVRA HETGSHRNIG WETFTDAVIK KLSEERENLV FMLWGSYAKE KASLIDTDKH 

       190        200        210        220 
LILTAVHPSP RSADYGFFGC KHFSKANTFL RSRGIEEIDW

« Hide

References

[1]"Extensive DNA inversions in the B. fragilis genome control variable gene expression."
Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. expand/collapse author list , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J.
Science 307:1463-1465(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25285 / NCTC 9343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR626927 Genomic DNA. Translation: CAH09007.1.
RefSeqYP_212924.1. NC_003228.3.

3D structure databases

ProteinModelPortalQ5LA67.
ModBaseSearch...

Protein-protein interaction databases

STRING272559.BF3312.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH09007; CAH09007; BF9343_3226.
GeneID3286696.
KEGGbfs:BF3312.
PATRIC21043322. VBIBacFra29119_3373.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0692.
KOK03648.
OMAGIEEIDW.
ProtClustDBPRK05254.

Family and domain databases

Gene3D3.40.470.10. 1 hit.
HAMAPMF_00148. UDG.
InterProIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERPTHR11264. PTHR11264. 1 hit.
PfamPF03167. UDG. 1 hit.
[Graphical view]
SMARTSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMSSF52141. UDNA_glycsylseSF. 1 hit.
TIGRFAMsTIGR00628. ung. 1 hit.
PROSITEPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUNG1_BACFN
AccessionPrimary (citable) accession number: Q5LA67
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 21, 2005
Last modified: May 29, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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