Reviewed, UniProtKB/Swiss-Prot Q5L9N9 (KGUA_BACFN)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	BF3500

Organism

Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]

Taxonomic identifier

272559 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Guanylate kinase HAMAP MF_00328		PRO_0000266289
Regions
	Domain	16 – 196	181	Guanylate kinase-like
	Nucleotide binding	23 – 30	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5L9N9-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 5D62E22010247C60	FASTA	204	22,980
	10 20 30 40 50 60 MNPTERITTP HKTGEAKVII FSAPSGSGKS TIINYLLAQK LNLAFSISAT SRPPRGNEKH 70 80 90 100 110 120 GVEYFFLSPD EFRQRIANNE FLEYEEVYTD RFYGTLKAQV EKQLAAGQNV VFDVDVVGGC 130 140 150 160 170 180 NIKKYYGERA LSLFIQPPCI DELRRRLIGR GTDTPEVIES RIAKAEYELS FAPKFDKVII 190 200 NDDLETAKAH ALKVIKEFLG IDTE

References

[1]

"Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J. Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR626927 Genomic DNA. Translation: CAH09188.1.
RefSeq	YP_213102.1.
3D structure databases
HSSP	HSSP built from PDB template 1S96 based on UniProtKB P60546.
SMR	Q5L9N9. Positions 16-195.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5L9N9.
Genome annotation databases
GeneID	3289181.
GenomeReviews	Gene locus BF3500 in contig CR626927_GR.
KEGG	bfs:BF3500.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HBG671982.
OMA	EWAEFAG.
Enzyme and pathway databases
BioCyc	BFRA272559:BF3500-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BACFN

Accession

Primary (citable) accession number: Q5L9N9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	June 21, 2005
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)