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Q5L9J7

- Q5L9J7_BACFN

UniProt

Q5L9J7 - Q5L9J7_BACFN

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-3500-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
ORF Names:BF9343_3449Imported
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)Imported
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272559.BF3542.

Structurei

3D structure databases

ProteinModelPortaliQ5L9J7.
SMRiQ5L9J7. Positions 9-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiTNLFMDV.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5L9J7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKITKQQNG VLSVPDVPTI PFITGDGVGA EITPAMQAIV DAAVDMSYGG
60 70 80 90 100
VRRIEWKEVL AGERAFRATG SWLPDETMEV FKEYLIGIKG PLTTPVGGGI
110 120 130 140 150
RSLNVALRQT LDLYVCLRPV RWFRGVVSPV KEPEKVKMYI FRENTEDIYA
160 170 180 190 200
GIEWEAGTPE AKKFYRFLHE EMGVSKVRFP ETSSFGVKPV SREGTERLVR
210 220 230 240 250
AACRYALQHE LPSVTLVHKG NIMKFTEGGF KKWGYELAER EFADALASGK
260 270 280 290 300
LVIKDCIADA FLQNTLLIPE EYSVIATLNL NGDYISDQLA AMVGGIGIAP
310 320 330 340 350
GANINYDSGH AIFEATHGTA PNIAGKNVVN PCSLILSAVM MLEYIGWQEP
360 370 380 390
ADLIVEALEA SFAEGKATND LARFMHKGQP LSTSEFTREI INRIKN
Length:396
Mass (Da):43,596
Last modified:June 21, 2005 - v1
Checksum:iD02DAEEA34F996BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA. Translation: CAH09230.1.
RefSeqiWP_010993458.1. NC_003228.3.
YP_213144.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH09230; CAH09230; BF9343_3449.
GeneIDi3287902.
KEGGibfs:BF3542.
PATRICi21043812. VBIBacFra29119_3616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA. Translation: CAH09230.1 .
RefSeqi WP_010993458.1. NC_003228.3.
YP_213144.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5L9J7.
SMRi Q5L9J7. Positions 9-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF3542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH09230 ; CAH09230 ; BF9343_3449 .
GeneIDi 3287902.
KEGGi bfs:BF3542.
PATRICi 21043812. VBIBacFra29119_3616.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi TNLFMDV.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci BFRA272559:GKF0-3500-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343Imported.

Entry informationi

Entry nameiQ5L9J7_BACFN
AccessioniPrimary (citable) accession number: Q5L9J7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3