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Q5L9J7

- Q5L9J7_BACFN

UniProt

Q5L9J7 - Q5L9J7_BACFN

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBFRA272559:GKF0-3500-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    ORF Names:BF9343_3449Imported
    OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)Imported
    Taxonomic identifieri272559 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000006731: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi272559.BF3542.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5L9J7.
    SMRiQ5L9J7. Positions 9-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiTNLFMDV.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5L9J7-1 [UniParc]FASTAAdd to Basket

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    MSKITKQQNG VLSVPDVPTI PFITGDGVGA EITPAMQAIV DAAVDMSYGG    50
    VRRIEWKEVL AGERAFRATG SWLPDETMEV FKEYLIGIKG PLTTPVGGGI 100
    RSLNVALRQT LDLYVCLRPV RWFRGVVSPV KEPEKVKMYI FRENTEDIYA 150
    GIEWEAGTPE AKKFYRFLHE EMGVSKVRFP ETSSFGVKPV SREGTERLVR 200
    AACRYALQHE LPSVTLVHKG NIMKFTEGGF KKWGYELAER EFADALASGK 250
    LVIKDCIADA FLQNTLLIPE EYSVIATLNL NGDYISDQLA AMVGGIGIAP 300
    GANINYDSGH AIFEATHGTA PNIAGKNVVN PCSLILSAVM MLEYIGWQEP 350
    ADLIVEALEA SFAEGKATND LARFMHKGQP LSTSEFTREI INRIKN 396
    Length:396
    Mass (Da):43,596
    Last modified:June 21, 2005 - v1
    Checksum:iD02DAEEA34F996BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR626927 Genomic DNA. Translation: CAH09230.1.
    RefSeqiWP_010993458.1. NC_003228.3.
    YP_213144.1. NC_003228.3.

    Genome annotation databases

    EnsemblBacteriaiCAH09230; CAH09230; BF9343_3449.
    GeneIDi3287902.
    KEGGibfs:BF3542.
    PATRICi21043812. VBIBacFra29119_3616.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR626927 Genomic DNA. Translation: CAH09230.1 .
    RefSeqi WP_010993458.1. NC_003228.3.
    YP_213144.1. NC_003228.3.

    3D structure databases

    ProteinModelPortali Q5L9J7.
    SMRi Q5L9J7. Positions 9-393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272559.BF3542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH09230 ; CAH09230 ; BF9343_3449 .
    GeneIDi 3287902.
    KEGGi bfs:BF3542.
    PATRICi 21043812. VBIBacFra29119_3616.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi TNLFMDV.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci BFRA272559:GKF0-3500-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25285 / NCTC 9343Imported.

    Entry informationi

    Entry nameiQ5L9J7_BACFN
    AccessioniPrimary (citable) accession number: Q5L9J7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 21, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3