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Q5L9J7

- Q5L9J7_BACFN

UniProt

Q5L9J7 - Q5L9J7_BACFN

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Protein

Isocitrate dehydrogenase [NADP]

Gene
icd, BF9343_3449
Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-3500-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
ORF Names:BF9343_3449Imported
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)Imported
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272559.BF3542.

Structurei

3D structure databases

ProteinModelPortaliQ5L9J7.
SMRiQ5L9J7. Positions 9-393.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiTNLFMDV.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5L9J7-1 [UniParc]FASTAAdd to Basket

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MSKITKQQNG VLSVPDVPTI PFITGDGVGA EITPAMQAIV DAAVDMSYGG    50
VRRIEWKEVL AGERAFRATG SWLPDETMEV FKEYLIGIKG PLTTPVGGGI 100
RSLNVALRQT LDLYVCLRPV RWFRGVVSPV KEPEKVKMYI FRENTEDIYA 150
GIEWEAGTPE AKKFYRFLHE EMGVSKVRFP ETSSFGVKPV SREGTERLVR 200
AACRYALQHE LPSVTLVHKG NIMKFTEGGF KKWGYELAER EFADALASGK 250
LVIKDCIADA FLQNTLLIPE EYSVIATLNL NGDYISDQLA AMVGGIGIAP 300
GANINYDSGH AIFEATHGTA PNIAGKNVVN PCSLILSAVM MLEYIGWQEP 350
ADLIVEALEA SFAEGKATND LARFMHKGQP LSTSEFTREI INRIKN 396
Length:396
Mass (Da):43,596
Last modified:June 21, 2005 - v1
Checksum:iD02DAEEA34F996BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH09230.1.
RefSeqiWP_010993458.1. NC_003228.3.
YP_213144.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH09230; CAH09230; BF9343_3449.
GeneIDi3287902.
KEGGibfs:BF3542.
PATRICi21043812. VBIBacFra29119_3616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH09230.1 .
RefSeqi WP_010993458.1. NC_003228.3.
YP_213144.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5L9J7.
SMRi Q5L9J7. Positions 9-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF3542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH09230 ; CAH09230 ; BF9343_3449 .
GeneIDi 3287902.
KEGGi bfs:BF3542.
PATRICi 21043812. VBIBacFra29119_3616.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi TNLFMDV.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci BFRA272559:GKF0-3500-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiQ5L9J7_BACFN
AccessioniPrimary (citable) accession number: Q5L9J7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 21, 2005
Last sequence update: June 21, 2005
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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