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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-3500-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
ORF Names:BF9343_3449Imported
OrganismiBacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)Imported
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272559.BF3542.

Structurei

3D structure databases

ProteinModelPortaliQ5L9J7.
SMRiQ5L9J7. Positions 9-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5L9J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKITKQQNG VLSVPDVPTI PFITGDGVGA EITPAMQAIV DAAVDMSYGG
60 70 80 90 100
VRRIEWKEVL AGERAFRATG SWLPDETMEV FKEYLIGIKG PLTTPVGGGI
110 120 130 140 150
RSLNVALRQT LDLYVCLRPV RWFRGVVSPV KEPEKVKMYI FRENTEDIYA
160 170 180 190 200
GIEWEAGTPE AKKFYRFLHE EMGVSKVRFP ETSSFGVKPV SREGTERLVR
210 220 230 240 250
AACRYALQHE LPSVTLVHKG NIMKFTEGGF KKWGYELAER EFADALASGK
260 270 280 290 300
LVIKDCIADA FLQNTLLIPE EYSVIATLNL NGDYISDQLA AMVGGIGIAP
310 320 330 340 350
GANINYDSGH AIFEATHGTA PNIAGKNVVN PCSLILSAVM MLEYIGWQEP
360 370 380 390
ADLIVEALEA SFAEGKATND LARFMHKGQP LSTSEFTREI INRIKN
Length:396
Mass (Da):43,596
Last modified:June 21, 2005 - v1
Checksum:iD02DAEEA34F996BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA. Translation: CAH09230.1.
RefSeqiWP_010993458.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH09230; CAH09230; BF9343_3449.
KEGGibfs:BF9343_3449.
PATRICi21043812. VBIBacFra29119_3616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA. Translation: CAH09230.1.
RefSeqiWP_010993458.1. NC_003228.3.

3D structure databases

ProteinModelPortaliQ5L9J7.
SMRiQ5L9J7. Positions 9-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272559.BF3542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH09230; CAH09230; BF9343_3449.
KEGGibfs:BF9343_3449.
PATRICi21043812. VBIBacFra29119_3616.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-3500-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343Imported.

Entry informationi

Entry nameiQ5L9J7_BACFN
AccessioniPrimary (citable) accession number: Q5L9J7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 21, 2005
Last sequence update: June 21, 2005
Last modified: July 22, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.