Q5L9G0 (AROC_BACFN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BF3584

Organism

Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]

Taxonomic identifier

272559 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Chorismate synthase HAMAP MF_00300		PRO_0000256271

Sequences

	Sequence		Length	Mass (Da)
	Q5L9G0 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 63F98E4343B0EB14	FASTA	358	39,234
	10 20 30 40 50 60 MFNSFGNIFR LTSFGESHGK GIGGVIDGFP AGIVIDEEFV QQELSRRRPG QSVITTSRKE 70 80 90 100 110 120 ADKVEFLSGI FEGKSTGCPI GFIVWNENQH SNDYNNLEKV YRPSHADYTY TVKYGIRDHR 130 140 150 160 170 180 GGGRSSARET ISRVVGGALA KLALRQLGIH ITAYTSQVGP IKLEGNYTDY DLDLIETNPV 190 200 210 220 230 240 RCPDPEKAKE MQDLIYKIKG EGDTIGGVLT CVIKGCPIGL GQPVYGKLHA ALGNAMLSIN 250 260 270 280 290 300 AAKAFEYGDG FKGLKQKGSE QNDVFYNNNG RIETRTNHSG GIQGGISNGQ DIFFRVAFKP 310 320 330 340 350 VATVLMEQET VNIDGIDTTL KARGRHDPCV LPRAVPIVEA MAAMTILDYY LLDRMTQL

References

[1]

"Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J. Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25285 / NCTC 9343.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR626927 Genomic DNA. Translation: CAH09267.1.
RefSeq	YP_213181.1. NC_003228.3.
3D structure databases
HSSP	HSSP built from PDB template 1R53 based on UniProtKB P28777.
ProteinModelPortal	Q5L9G0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5L9G0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3289118.
GenomeReviews	Gene locus BF3584 in contig CR626927_GR.
KEGG	bfs:BF3584.
PATRIC	21043890. VBIBacFra29119_3655.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HBG292336.
OMA	GVQGGIS.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	BFRA272559:BF3584-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BACFN

Accession

Primary (citable) accession number: Q5L9G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	June 21, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program