Reviewed, UniProtKB/Swiss-Prot Q5L9E3 (G6PI_BACFN)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	BF3604

Organism

Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]

Taxonomic identifier

272559 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180596
Sites
	Active site	287	1	Proton donor By similarity
	Active site	308	1	By similarity
	Active site	422	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5L9E3-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: D2112CB217B7C65C	FASTA	445	48,750
	10 20 30 40 50 60 MISLNIEKTF GFISKESVSA YEAQVKAAQE ALENGTGKGN DFLGWLHLPS SISKEHLADL 70 80 90 100 110 120 KATAQVLRDN CEVVIVAGIG GSYLGARAVI EALSNSFTWL QEKKTAPVMI YAGHNIGEDY 130 140 150 160 170 180 LYELTEFLKD KKFGVINISK SGTTTETALA FRLLKKQCED QRGKEMAKKV IVAVTDAKKG 190 200 210 220 230 240 AARVTADKEG YKSFIIPDNV GGRFSVLTPV GLLPIAVAGF DIEQLVNGAA DMEKACGADV 250 260 270 280 290 300 PFAENPAAIY AATRNELYKN GKKIEILVNF CPKLHYVSEW WKQLYGESEG KDNKGIFPAA 310 320 330 340 350 360 VDFSTDLHSM GQWIQEGERT IFETVISVDK VNHKLEVPSD EANLDGLNFL AGKRVDEVNK 370 380 390 400 410 420 MAELGTQLAH VDGGVPNMRI VIPELSEFSI GQLLYFFEKA CGISGYLLGV NPFNQPGVEA 430 440 YKKNMFALLN KPGYEEESKA IQARL

References

[1]

"Extensive DNA inversions in the B. fragilis genome control variable gene expression." Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J. Science 307:1463-1465(2005) [PubMed: 15746427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR626927 Genomic DNA. Translation: CAH09285.1.
RefSeq	YP_213198.1.
3D structure databases
SMR	Q5L9E3. Positions 2-445.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5L9E3.
Genome annotation databases
GeneID	3287829.
GenomeReviews	Gene locus BF3604 in contig CR626927_GR.
KEGG	bfs:BF3604.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG615843.
OMA	TFIIPDN.
Enzyme and pathway databases
BioCyc	BFRA272559:BF3604-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_BACFN

Accession

Primary (citable) accession number: Q5L9E3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	June 21, 2005
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)