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Q5L9D9 (UNG2_BACFN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uracil-DNA glycosylase 2
Short name=UDG 2
EC=3.2.2.27
Gene names
Name:ung2
Ordered Locus Names:BF3608
OrganismBacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]
Taxonomic identifier272559 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides ›

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity. HAMAP-Rule MF_00148

Catalytic activity

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil. HAMAP-Rule MF_00148

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the uracil-DNA glycosylase family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processbase-excision repair

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuracil DNA N-glycosylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Uracil-DNA glycosylase 2 HAMAP-Rule MF_00148
PRO_0000176060

Sites

Active site651Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L9D9 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: 63BFB3CFD93566B6

FASTA22024,998
        10         20         30         40         50         60 
MNVQIEESWK THLEPEFEKD YFRTLTEFVR SEYSQYQIFP PGKLIFNAFN LCPFDKVKVV 

        70         80         90        100        110        120 
IIGQDPYHGP GQAHGLCFSV NDGVAFPPSL VNIFKEIKED IGTPAPSTGN LTRWAEQGVL 

       130        140        150        160        170        180 
LLNATLTVRA HQAGSHQRRG WEEFTDAAIR VLAEERENLV FILWGSYAQK KGAFIDRNKH 

       190        200        210        220 
LVLSSAHPSP LSAYNGFFGN KHFSKTNEYL KAHGKTEINW

« Hide

References

[1]"Extensive DNA inversions in the B. fragilis genome control variable gene expression."
Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A. expand/collapse author list , Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J.
Science 307:1463-1465(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25285 / NCTC 9343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR626927 Genomic DNA. Translation: CAH09289.1.
RefSeqYP_213202.1. NC_003228.3.

3D structure databases

ProteinModelPortalQ5L9D9.
SMRQ5L9D9. Positions 7-220.
ModBaseSearch...

Protein-protein interaction databases

STRING272559.BF3608.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH09289; CAH09289; BF9343_3508.
GeneID3285513.
KEGGbfs:BF3608.
PATRIC21043946. VBIBacFra29119_3682.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0692.
KOK03648.
OMAKEPINWK.
ProtClustDBPRK05254.

Family and domain databases

Gene3D3.40.470.10. 1 hit.
HAMAPMF_00148. UDG.
InterProIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERPTHR11264. PTHR11264. 1 hit.
PfamPF03167. UDG. 1 hit.
[Graphical view]
SMARTSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMSSF52141. UDNA_glycsylseSF. 1 hit.
TIGRFAMsTIGR00628. ung. 1 hit.
PROSITEPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUNG2_BACFN
AccessionPrimary (citable) accession number: Q5L9D9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 21, 2005
Last modified: May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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