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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:BF3673
OrganismiBacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000006731 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829121 – 324Methionyl-tRNA formyltransferaseAdd BLAST324

Interactioni

Protein-protein interaction databases

STRINGi272559.BF3673

Structurei

3D structure databases

ProteinModelPortaliQ5L975
SMRiQ5L975
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 116Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q5L975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEDLRIVY MGTPDFAVEA LQCLVEGGYN VVGVITMPDK PAGRGHKIQY
60 70 80 90 100
SPVKQYALDH QLPLLQPEKL KDEEFIQALR EWKADLQIVV AFRMLPEVVW
110 120 130 140 150
NMPRLGTFNL HASLLPQYRG AAPINWAVIN GDTETGITTF FLKHEIDTGE
160 170 180 190 200
VIQQVRIPIA DTDNVEIVHD KLMHLGGRLV IETVDAILEG KVKSIPQEEM
210 220 230 240 250
AVAGELRPAP KIFKETCRID WNQPVKRVYD FIRGLSPYPA AWSELVNPEG
260 270 280 290 300
EAVVVKIFES EKLPKVHTLA PGSIVTDGKN FLRVAVPDGF VNVLSLQLPG
310 320
KKRLKTDELL RGFHLTEAFK MKAV
Length:324
Mass (Da):36,389
Last modified:June 21, 2005 - v1
Checksum:i324EA580827CBF1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA Translation: CAH09355.1
RefSeqiWP_008770001.1, NC_003228.3

Genome annotation databases

EnsemblBacteriaiCAH09355; CAH09355; BF9343_3574
KEGGibfs:BF9343_3574

Entry informationi

Entry nameiFMT_BACFN
AccessioniPrimary (citable) accession number: Q5L975
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 21, 2005
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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