ID   Q5L943_BACFN            Unreviewed;       529 AA.
AC   Q5L943;
DT   21-JUN-2005, integrated into UniProtKB/TrEMBL.
DT   21-JUN-2005, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Sialidase {ECO:0000313|EMBL:CAH09389.1};
GN   ORFNames=BF9343_3608 {ECO:0000313|EMBL:CAH09389.1};
OS   Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019
OS   / NCTC 9343 / Onslow).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=272559 {ECO:0000313|EMBL:CAH09389.1, ECO:0000313|Proteomes:UP000006731};
RN   [1] {ECO:0000313|EMBL:CAH09389.1, ECO:0000313|Proteomes:UP000006731}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 /
RC   Onslow {ECO:0000313|Proteomes:UP000006731};
RX   PubMed=15746427; DOI=10.1126/science.1107008;
RA   Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V.,
RA   Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A.,
RA   Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A.,
RA   Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J.,
RA   Barrell B.G., Parkhill J.;
RT   "Extensive DNA inversions in the B. fragilis genome control variable gene
RT   expression.";
RL   Science 307:1463-1465(2005).
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DR   EMBL; CR626927; CAH09389.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5L943; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   PaxDb; 272559-BF9343_3608; -.
DR   KEGG; bfs:BF9343_3608; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_0_0_10; -.
DR   Proteomes; UP000006731; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR029456; Sialidase_N.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF14873; BNR_assoc_N; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006731}.
FT   DOMAIN          2..124
FT                   /note="Sialidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14873"
FT   DOMAIN          166..499
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   529 AA;  58835 MW;  8CE1A49E8C8E908E CRC64;
     MKVIVRQPIV PVLTKKEINP VLQLKLIKSC PGPCFVKEIG LSLKGTTLLT DLTHLSLYRV
     AGKRGLSDWE KCVDSVAPAL KTVLDTPLEL KSDTTILWVT VKLKDKVDLT HRVTVSCDHV
     TTTCGKASVT SVRPIVALRT GVAVRQRGED GVHTSRIPGI TTSLKGTLMA IFDARYDSSR
     DLQGDIDIAM MRSLDGGMSW QPMQIVLDRK KWGGLPEKYN GISDACILTD EKNGTIYVAG
     LWMYGVLDPR SGKWVEGMTQ DSTRWIHQWH AKGSQPGLGV KETCQFLITK SVDDGLTWSD
     PVNITAQTKK PEWWLYAPAP GHGITLKDGT LIFPTQGRDK DGIPFSNITY SKDGGKTWIA
     SKPAYHNTTE CMAVELQDGS VMLNMRDNRN HGNKKVNGRR ICVTSDLGST WTEHSTSRKA
     LIEPTCMASI HRHTYQENGR QKTLLLFCNP ESYDSRDHMT LKCSLDDGNT WDSGRKIMLD
     ELGSFGYSCI TSVNDSTIGV FYESSQAQMV FQQIQLKELI GKGKSYKER
//