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Q5L911 (NADK_BACFN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:BF3741
OrganismBacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]
Taxonomic identifier272559 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290NAD kinase HAMAP-Rule MF_00361
PRO_0000229609

Regions

Nucleotide binding72 – 732NAD By similarity
Nucleotide binding145 – 1462NAD By similarity
Nucleotide binding186 – 1916NAD By similarity

Sites

Active site721Proton acceptor By similarity
Binding site771NAD By similarity
Binding site1751NAD By similarity
Binding site2101NAD; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L911 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: C3448F29BBD7837C

FASTA29032,306
        10         20         30         40         50         60 
MKFAIFGNTY QAKKSSHAAT LFKLLEKHGA EICVCREFHR FLKSDLKLNV KADDLFDENN 

        70         80         90        100        110        120 
FDADMVISIG GDGTFLKAAR RVGNKGIPIL GINTGRLGFL ADVSPEEMEE TIEEVYQNHY 

       130        140        150        160        170        180 
TVEERSVLQL LCDDKHLQNS PYALNEIAIL KRDSSSMISI RTAINGAHLT TYQADGLIIA 

       190        200        210        220        230        240 
TPTGSTAYSL SVGGPIIVPH SKTIAITPVA PHSLNVRPIV ICDDWEITLD VESRSHNFLV 

       250        260        270        280        290 
AIDGSSETCK ETTRLTIRRA DYSIKVVKRF NHIFFDTLRT KMMWGADSRV 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR626927 Genomic DNA. Translation: CAH09421.1.
RefSeqYP_213330.1. NC_003228.3.

3D structure databases

ProteinModelPortalQ5L911.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272559.BF3741.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH09421; CAH09421; BF9343_3640.
GeneID3287998.
KEGGbfs:BF3741.
PATRIC21044230. VBIBacFra29119_3824.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMADDLHFET.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycBFRA272559:GKF0-3692-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_BACFN
AccessionPrimary (citable) accession number: Q5L911
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 21, 2005
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families