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Q5L8Z8

- MDH_BACFN

UniProt

Q5L8Z8 - MDH_BACFN

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331NADUniRule annotation
Binding sitei83 – 831SubstrateUniRule annotation
Binding sitei89 – 891SubstrateUniRule annotation
Binding sitei96 – 961NADUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Active sitei176 – 1761Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136NADUniRule annotation
Nucleotide bindingi119 – 1213NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-3710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:BF3753
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Malate dehydrogenasePRO_0000113427Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272559.BF3753.

Structurei

3D structure databases

ProteinModelPortaliQ5L8Z8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000021225.
KOiK00024.
OMAiNCKMLES.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5L8Z8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKVTVVGAG NVGATCANVL AFNEVADEVV MLDVKEGVSE GKAMDMMQTA
60 70 80 90 100
QLLGFDTTIV GCTNDYAQTA NSDVVVITSG IPRKPGMTRE ELIGVNAGIV
110 120 130 140 150
KSVAENLLKY SPNAIIVVIS NPMDTMTYLA LKSLGLPKNR VIGMGGALDS
160 170 180 190 200
SRFKYFLSQA LGCNANEVEG MVIGGHGDTT MIPLARLATY KGQPVSTLLS
210 220 230 240 250
EEKLNEVVAS TMVGGATLTK LLGTSAWYAP GAAGAYVVES IIHNQKKMVP
260 270 280 290 300
CSVMLEGEYG ESDLCIGVPV ILGKNGIEKI VELELNADEK AKFAASAAAV
310
HKTNAALKEV GAL
Length:313
Mass (Da):32,676
Last modified:June 21, 2005 - v1
Checksum:iF3C4B9F01445DC14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH09434.1.
RefSeqiYP_213343.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH09434; CAH09434; BF9343_3653.
GeneIDi3288052.
KEGGibfs:BF3753.
PATRICi21044266. VBIBacFra29119_3838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH09434.1 .
RefSeqi YP_213343.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5L8Z8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF3753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH09434 ; CAH09434 ; BF9343_3653 .
GeneIDi 3288052.
KEGGi bfs:BF3753.
PATRICi 21044266. VBIBacFra29119_3838.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000021225.
KOi K00024.
OMAi NCKMLES.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci BFRA272559:GKF0-3710-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiMDH_BACFN
AccessioniPrimary (citable) accession number: Q5L8Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 21, 2005
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3