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Q5L8Z8 (MDH_BACFN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:BF3753
OrganismBacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Complete proteome] [HAMAP]
Taxonomic identifier272559 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Malate dehydrogenase HAMAP-Rule MF_00487
PRO_0000113427

Regions

Nucleotide binding8 – 136NAD By similarity
Nucleotide binding119 – 1213NAD By similarity

Sites

Active site1761Proton acceptor By similarity
Binding site331NAD By similarity
Binding site831Substrate By similarity
Binding site891Substrate By similarity
Binding site961NAD By similarity
Binding site1211Substrate By similarity
Binding site1521Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L8Z8 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: F3C4B9F01445DC14

FASTA31332,676
        10         20         30         40         50         60 
MSKVTVVGAG NVGATCANVL AFNEVADEVV MLDVKEGVSE GKAMDMMQTA QLLGFDTTIV 

        70         80         90        100        110        120 
GCTNDYAQTA NSDVVVITSG IPRKPGMTRE ELIGVNAGIV KSVAENLLKY SPNAIIVVIS 

       130        140        150        160        170        180 
NPMDTMTYLA LKSLGLPKNR VIGMGGALDS SRFKYFLSQA LGCNANEVEG MVIGGHGDTT 

       190        200        210        220        230        240 
MIPLARLATY KGQPVSTLLS EEKLNEVVAS TMVGGATLTK LLGTSAWYAP GAAGAYVVES 

       250        260        270        280        290        300 
IIHNQKKMVP CSVMLEGEYG ESDLCIGVPV ILGKNGIEKI VELELNADEK AKFAASAAAV 

       310 
HKTNAALKEV GAL 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR626927 Genomic DNA. Translation: CAH09434.1.
RefSeqYP_213343.1. NC_003228.3.

3D structure databases

ProteinModelPortalQ5L8Z8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272559.BF3753.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH09434; CAH09434; BF9343_3653.
GeneID3288052.
KEGGbfs:BF3753.
PATRIC21044266. VBIBacFra29119_3838.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000021225.
KOK00024.
OMANCKMLES.
OrthoDBEOG6091FG.

Enzyme and pathway databases

BioCycBFRA272559:GKF0-3710-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_BACFN
AccessionPrimary (citable) accession number: Q5L8Z8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 21, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families