ID   A0A380YS77_BACFN        Unreviewed;       544 AA.
AC   A0A380YS77; Q5L868;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Neuraminidase {ECO:0000313|EMBL:CAH09725.1};
GN   Name=nanH2 {ECO:0000313|EMBL:CAH09725.1};
GN   ORFNames=BF9343_3944 {ECO:0000313|EMBL:CAH09725.1};
OS   Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019
OS   / NCTC 9343 / Onslow).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=272559 {ECO:0000313|EMBL:CAH09725.1, ECO:0000313|Proteomes:UP000006731};
RN   [1] {ECO:0000313|EMBL:CAH09725.1, ECO:0000313|Proteomes:UP000006731}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 /
RC   Onslow {ECO:0000313|Proteomes:UP000006731};
RX   PubMed=15746427; DOI=10.1126/science.1107008;
RA   Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V.,
RA   Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A.,
RA   Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A.,
RA   Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J.,
RA   Barrell B.G., Parkhill J.;
RT   "Extensive DNA inversions in the B. fragilis genome control variable gene
RT   expression.";
RL   Science 307:1463-1465(2005).
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DR   EMBL; CR626927; CAH09725.1; -; Genomic_DNA.
DR   RefSeq; WP_005822175.1; NZ_UFTH01000001.1.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   PaxDb; 272559-BF9343_3944; -.
DR   KEGG; bfs:BF9343_3944; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_0_0_10; -.
DR   BRENDA; 3.2.1.18; 755.
DR   Proteomes; UP000006731; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.1290; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR029456; Sialidase_N.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF14873; BNR_assoc_N; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006731};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..544
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5041071824"
FT   DOMAIN          22..172
FT                   /note="Sialidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14873"
FT   DOMAIN          206..485
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
SQ   SEQUENCE   544 AA;  60366 MW;  745E6862868C9F0D CRC64;
     MKFYLLFIFI SLNLCSFSAR ATDTIFVYET QVPILIERQD NMLFLMRLTT ARSDTKLNEV
     VLRLGQNVNL SNIQSIKLYY GGTEARQNYG KELYLPVTYI SRDVSGKTLA ANPSYSINKS
     QVNNPGRKVI LNANQKLFPG INYFWISLQM KPGASLLDKV SAKIVTVKVD NKEALIYTVS
     PENITHRVGV GVRHAGDDGS AAFRIPGLAT TNKGTLLGVY DVRYNSSVDL QEHMDVGLSR
     SVDGGKTWEK MRLPLAFGET GGLPAAQNGV GDPSILVDTK TNTTWVVAAW THGMGNQRAW
     WSSYPGMDMN HTAQLVLSKS TDDGKTWSEP INITDQVKEP SWYFLLQGPG RGITMQDGTL
     VFPIQFIDST RVPNAGIMYS KDRGETWKIH NYARTNTTEA QVAEVEPGVL MLNMRDNRGG
     SRAVATTKDL GKTWTEHPSS RKALQEPVCM ASLISVKAAD NTLNKDILLF SNPNTVKGRH
     HITIKASLDG GITWLPEHQV MLDEGDGWGY SCLTMIDKET VGILYESSVA HMTFQAIRLR
     DIIQ
//