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Q5L7Z7

- PNP_BACFN

UniProt

Q5L7Z7 - PNP_BACFN

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi490 – 4901MagnesiumUniRule annotation
    Metal bindingi496 – 4961MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciBFRA272559:GKF0-4099-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:BF4129
    OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
    Taxonomic identifieri272559 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000006731: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 708708Polyribonucleotide nucleotidyltransferasePRO_0000329523Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272559.BF4129.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5L7Z7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini557 – 61963KHUniRule annotationAdd
    BLAST
    Domaini629 – 69971S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiGTENTIC.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5L7Z7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINPIVKTIE LGDGRTITLE TGKLAKQADG SVMLRMGNTM LLATVCAAKD    50
    AVPGTDFMPL QVEYKEKFAA FGRFPGGFTK REGRASDYEI LTCRLVDRAL 100
    RPLFPDNYHA EVYVNIILFS ADGVDMPDAL AGLAASAALA VSDIPFNGPI 150
    SEVRVARIDG KFVINPTFDQ LEQADMDIMV AATYENIMMV EGEMSEVSEA 200
    ELLEAMKVAH EAIKVHCKAQ MELTEMVGKT VKREYCHEEN DEELRKAVHD 250
    ACYDKSYAIA ASGNRNKHER QDAFDAIRDE FKAQFSEEEL EEKGALIDRY 300
    YHDVEKEAMR RCILDEGKRL DGRKTTEIRP IWCEVGYLPG PHGSAIFTRG 350
    ETQSLTSVTL GTKLDEKIID DVLAHGKERF LLHYNFPPFS TGEAKAQRGV 400
    GRREIGHGNL AHRALKRMIP EDYPYVVRVV SDILESNGSS SMATVCAGTL 450
    ALMDAGVKIK KPVSGIAMGL IKNAGEEKYA VLSDILGDED HLGDMDFKVT 500
    GTKDGITATQ MDIKVDGLSY EILERALNQA KEGRMHILGK IEETISEPRT 550
    ELKDHAPRIE TMTIPKEFIG AVIGPGGKII QGMQEETGAT ITIEEIDNVG 600
    RIEISGTNKK SIDDAIRLIK GIVAVPEVGE VYKGKVRSIM PYGAFVEFLP 650
    GKDGLLHISE IDWKRLETVE EAGIKEGDEI EVKLIDIDPK TGKFKLSRKV 700
    LLPRPEKK 708
    Length:708
    Mass (Da):78,309
    Last modified:June 21, 2005 - v1
    Checksum:iD60D26CC53A7E240
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR626927 Genomic DNA. Translation: CAH09802.1.
    RefSeqiYP_213694.1. NC_003228.3.

    Genome annotation databases

    EnsemblBacteriaiCAH09802; CAH09802; BF9343_4021.
    GeneIDi3287979.
    KEGGibfs:BF4129.
    PATRICi21045113. VBIBacFra29119_4240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR626927 Genomic DNA. Translation: CAH09802.1 .
    RefSeqi YP_213694.1. NC_003228.3.

    3D structure databases

    ProteinModelPortali Q5L7Z7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272559.BF4129.

    Protocols and materials databases

    DNASUi 3287979.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH09802 ; CAH09802 ; BF9343_4021 .
    GeneIDi 3287979.
    KEGGi bfs:BF4129.
    PATRICi 21045113. VBIBacFra29119_4240.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi GTENTIC.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci BFRA272559:GKF0-4099-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25285 / NCTC 9343.

    Entry informationi

    Entry nameiPNP_BACFN
    AccessioniPrimary (citable) accession number: Q5L7Z7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3