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Q5L7Z7

- PNP_BACFN

UniProt

Q5L7Z7 - PNP_BACFN

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, BF4129
Organism
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi490 – 4901Magnesium By similarity
Metal bindingi496 – 4961Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-4099-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:BF4129
OrganismiBacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000006731: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000329523Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272559.BF4129.

Structurei

3D structure databases

ProteinModelPortaliQ5L7Z7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini557 – 61963KHAdd
BLAST
Domaini629 – 69971S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5L7Z7-1 [UniParc]FASTAAdd to Basket

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MINPIVKTIE LGDGRTITLE TGKLAKQADG SVMLRMGNTM LLATVCAAKD    50
AVPGTDFMPL QVEYKEKFAA FGRFPGGFTK REGRASDYEI LTCRLVDRAL 100
RPLFPDNYHA EVYVNIILFS ADGVDMPDAL AGLAASAALA VSDIPFNGPI 150
SEVRVARIDG KFVINPTFDQ LEQADMDIMV AATYENIMMV EGEMSEVSEA 200
ELLEAMKVAH EAIKVHCKAQ MELTEMVGKT VKREYCHEEN DEELRKAVHD 250
ACYDKSYAIA ASGNRNKHER QDAFDAIRDE FKAQFSEEEL EEKGALIDRY 300
YHDVEKEAMR RCILDEGKRL DGRKTTEIRP IWCEVGYLPG PHGSAIFTRG 350
ETQSLTSVTL GTKLDEKIID DVLAHGKERF LLHYNFPPFS TGEAKAQRGV 400
GRREIGHGNL AHRALKRMIP EDYPYVVRVV SDILESNGSS SMATVCAGTL 450
ALMDAGVKIK KPVSGIAMGL IKNAGEEKYA VLSDILGDED HLGDMDFKVT 500
GTKDGITATQ MDIKVDGLSY EILERALNQA KEGRMHILGK IEETISEPRT 550
ELKDHAPRIE TMTIPKEFIG AVIGPGGKII QGMQEETGAT ITIEEIDNVG 600
RIEISGTNKK SIDDAIRLIK GIVAVPEVGE VYKGKVRSIM PYGAFVEFLP 650
GKDGLLHISE IDWKRLETVE EAGIKEGDEI EVKLIDIDPK TGKFKLSRKV 700
LLPRPEKK 708
Length:708
Mass (Da):78,309
Last modified:June 21, 2005 - v1
Checksum:iD60D26CC53A7E240
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH09802.1.
RefSeqiYP_213694.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH09802; CAH09802; BF9343_4021.
GeneIDi3287979.
KEGGibfs:BF4129.
PATRICi21045113. VBIBacFra29119_4240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR626927 Genomic DNA. Translation: CAH09802.1 .
RefSeqi YP_213694.1. NC_003228.3.

3D structure databases

ProteinModelPortali Q5L7Z7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272559.BF4129.

Protocols and materials databases

DNASUi 3287979.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH09802 ; CAH09802 ; BF9343_4021 .
GeneIDi 3287979.
KEGGi bfs:BF4129.
PATRICi 21045113. VBIBacFra29119_4240.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci BFRA272559:GKF0-4099-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25285 / NCTC 9343.

Entry informationi

Entry nameiPNP_BACFN
AccessioniPrimary (citable) accession number: Q5L7Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 21, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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