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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBFRA272559:GKF0-4128-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:BF4219
OrganismiBacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000006731 Componenti: Chromosome

Subcellular locationi

Q5L7Q8:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002419871 – 597Arginine--tRNA ligaseAdd BLAST597

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272559.BF4219.

Structurei

3D structure databases

ProteinModelPortaliQ5L7Q8.
SMRiQ5L7Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi125 – 135"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75. Bacteria.
COG0018. LUCA.
KOiK01887.
OMAiNKPLHLG.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR036695. Arg-tRNA-synth_N_sf.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5L7Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIEDKLVTS VISGLKALYG QDVPAAQVQL QKTKKEFEGH LTLVVFPFLK
60 70 80 90 100
MSKKGPEQTA QEIGEYLKAN EPAVAAFNVI KGFLNLTVAS ATWIELLNEI
110 120 130 140 150
HTDAQYGIVS ADENAPLVMI EYSSPNTNKP LHLGHVRNNL LGNALANIVM
160 170 180 190 200
ANGNKVVKTN IVNDRGIHIC KSMLAWQKYG KGETPESSGK KGDHLVGDYY
210 220 230 240 250
VAFDKHYKAE VAELMEKGMS KEEAEAASPL MNEAREMLVK WEAGDPEVRA
260 270 280 290 300
LWQMMNNWVY AGFDETYRKM GVGFDKIYYE SNTYLEGKEK VMEGLEKGFF
310 320 330 340 350
FKKEDGSVWA DLTAEGLDHK LLLRGDGTSV YMTQDIGTAK LRFADYPIDK
360 370 380 390 400
MIYVVGNEQN YHFQVLSILL DKLGFEWGKS LVHFSYGMVE LPEGKMKSRE
410 420 430 440 450
GTVVDADDLM AEMIATAKET SQELGKLDGL TQEEADDIAR IVGLGALKYF
460 470 480 490 500
ILKVDARKNM TFNPKESIDF NGNTGPFIQY TYARIRSVLR KAAEAGIVIP
510 520 530 540 550
EVLPANIELS EKEEGLIQMV ADFAAVVRQA GEDYSPSGIA NYVYDLVKEY
560 570 580 590
NQFYHDFSIL REENEDVKLF RIALSANIAK VVRLGMGLLG IEVPDRM
Length:597
Mass (Da):66,759
Last modified:June 21, 2005 - v1
Checksum:i50B19C6F64735124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA. Translation: CAH09892.1.
RefSeqiWP_010993767.1. NC_003228.3.

Genome annotation databases

EnsemblBacteriaiCAH09892; CAH09892; BF9343_4111.
KEGGibfs:BF9343_4111.

Similar proteinsi

Entry informationi

Entry nameiSYR_BACFN
AccessioniPrimary (citable) accession number: Q5L7Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 21, 2005
Last modified: October 25, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families