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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei720ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BF4372
OrganismiBacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Taxonomic identifieri272559 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000006731 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000092931 – 943Leucine--tRNA ligaseAdd BLAST943

Proteomic databases

PRIDEiQ5L7B4

Interactioni

Protein-protein interaction databases

STRINGi272559.BF4372

Structurei

3D structure databases

ProteinModelPortaliQ5L7B4
SMRiQ5L7B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi717 – 721"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q5L7B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYNFREIEK KWQKIWVDNH TYQVNEDASK QKFYVLNMFP YPSGAGLHVG
60 70 80 90 100
HPLGYIASDI YARYKRLQGF NVLNPMGYDA YGLPAEQYAI QTGQHPAITT
110 120 130 140 150
VNNINRYREQ LDKIGFSFDW NREIRTCDPE YYHWTQWAFI KMFNSYYCND
160 170 180 190 200
EKQARPIEEL IEAFSTNGTQ GMNVACGEEM DFTADEWNAK SEKEQQEILM
210 220 230 240 250
NYRIAYLGNT MVNWCPALGT VLANDEVVDG VSERGGYPVI QKVMRQWCLR
260 270 280 290 300
VSAYAQRLLD GLETVEWTDS LKETQRNWIG RSEGAEMNFK VKDSDIEFTI
310 320 330 340 350
FTTRADTVFG VTFMVLAPES ELVAKLTTPE QKAEVDAYLD RTKKRTERER
360 370 380 390 400
IADRSVSGVF SGSYAINPLT NEPIPVWISD YVLAGYGTGA IMAVPAHDSR
410 420 430 440 450
DYAFAKHFNL EIRPLIEGCD VSEESFDAKE GIMMNSPRPG APEGGLVLNG
460 470 480 490 500
LTVKEAIAKT KEYIKATGLG RVKVNFRLRD AIFSRQRYWG EPFPVYYKDG
510 520 530 540 550
MPYMIDESCL PLELPEVAKF LPTETGEPPL GHATKWAWDT VNKCVTDNEN
560 570 580 590 600
IDNITIFPLE LNTMPGFAGS SAYYLRYMDP RNHEALVSPA VDQYWKNVDL
610 620 630 640 650
YVGGTEHATG HLIYSRFWNK FLHDWGISVA EEPFQKLVNQ GMIQGRSNFV
660 670 680 690 700
YRIKDTNTFV SLNLKDQYEV TPIHVDVNIV SNDILDLEAF KAWRPEYETA
710 720 730 740 750
EFILEDGKYI CGWAVEKMSK SMFNVVNPDM IVEKYGADTL RMYEMFLGPV
760 770 780 790 800
EQSKPWDTNG IDGVHRFIKK FWSLFYDRNG EYLVKDEPAT KEELKALHKL
810 820 830 840 850
IKKVTGDIEQ FSYNTSVSAF MICVNELSSL KCNKKEVLEQ LIVVLAPFAP
860 870 880 890 900
HVCEELWDTL GSTTSVCDAQ WPAFNEQYLV EDTVNYTISF NGKARFNMEF
910 920 930 940
PANAASDAIQ ATVLADERSL KWTEGKTPKK VIVVPKKIVN IVI
Length:943
Mass (Da):107,868
Last modified:June 21, 2005 - v1
Checksum:i50A0499C6FD5A16C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626927 Genomic DNA Translation: CAH10038.1
RefSeqiWP_010993827.1, NC_003228.3

Genome annotation databases

EnsemblBacteriaiCAH10038; CAH10038; BF9343_4257
KEGGibfs:BF9343_4257

Similar proteinsi

Entry informationi

Entry nameiSYL_BACFN
AccessioniPrimary (citable) accession number: Q5L7B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 21, 2005
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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