Reviewed, UniProtKB/Swiss-Prot Q5L789 (KDSA_CHLAB)

Names and origin

Protein names

Recommended name:
    2-dehydro-3-deoxyphosphooctonate aldolase
    EC=2.5.1.55
Alternative name(s):
    Phospho-2-dehydro-3-deoxyoctonate aldolase
    3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase
    KDO-8-phosphate synthetase
      Short name=KDO 8-P synthase
      Short name=KDOPS

Gene names

Name:	kdsA
Ordered Locus Names:	CAB021

Organism

Chlamydophila abortus [Complete proteome] [HAMAP]

Taxonomic identifier

83555 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the kdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000304443

Sequences

	Sequence		Length	Mass (Da)
	Q5L789-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 96F73DE0FDE937EF	FASTA	269	29,304
	10 20 30 40 50 60 MFSDKMILIA GPCVIEEEET TLEIAAKIQE IVAPYADHIH WIFKSSYDKA NRSSIHSYRG 70 80 90 100 110 120 PGLKEGLRIL SKVKQTFGVE ILTDVHSPEE ARAAAEVCDI LQIPAFLCRQ TDLLVAAAET 130 140 150 160 170 180 QAVINIKKGQ FLSPWDMQGP VDKVLSTGNS KIILTERGCS FGYNNLVSDM RAIAVLSKMG 190 200 210 220 230 240 FPVVFDGTHS VQLPGGLKTH SGGQTEFIPT LTRAALAAGA HGLFIETHTN PAIAKSDAAS 250 260 MLSLKAFEVL LPVWNQLYQC VRSFEMASV

References

[1]

"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation." Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D. Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S26/3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR848038 Genomic DNA. Translation: CAH63479.1.
RefSeq	YP_219453.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3337436.
GenomeReviews	Gene locus CAB021 in contig CR848038_GR.
KEGG	cab:CAB021.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5L789.
OMA	VYKTSFD.
Enzyme and pathway databases
BioCyc	CABO218497:CAB021-MON.
BRENDA	2.5.1.55. 292247.
Family and domain databases
HAMAP	MF_00056. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_CHLAB

Accession

Primary (citable) accession number: Q5L789

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 21, 2005
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)